ID Q237M6_TETTS Unreviewed; 634 AA.
AC Q237M6;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Glycosyl hydrolase family 35 protein {ECO:0000313|EMBL:EAR92715.1};
GN ORFNames=TTHERM_00321600 {ECO:0000313|EMBL:EAR92715.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR92715.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR EMBL; GG662743; EAR92715.1; -; Genomic_DNA.
DR RefSeq; XP_001012960.1; XM_001012960.1.
DR AlphaFoldDB; Q237M6; -.
DR STRING; 312017.Q237M6; -.
DR EnsemblProtists; EAR92715; EAR92715; TTHERM_00321600.
DR GeneID; 7825157; -.
DR KEGG; tet:TTHERM_00321600; -.
DR eggNOG; KOG0496; Eukaryota.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; Q237M6; -.
DR OMA; HERQYLH; -.
DR OrthoDB; 276766at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAR92715.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 54..368
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 415..529
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 555..611
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 202
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 276
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 634 AA; 71838 MW; 1C3A5683EB89E3EC CRC64;
MNKVALIASF LAGLSILSIS FVYLNQKDLK AEVIITNPPF NTTFPQTFEL KDQQFVLNGQ
PLYVAAGEIH YSRVPSQYWR TRIQTIKALG LNTLSVYIMW NHHEVAPGVF DFSSPDRNLR
NFLQIALEEQ MYVLIRPGPY VCAEWDFGGQ PFWLLKENVE LRSTDPKYIQ AITPYINRVA
QEIQDYQITR NGTVLMVQIE NEFGSYGSNN TYPLKLKQIW DDTKKIQVPY YTADGGSLIK
TGHVPGAAFG LNPGTNEKDY LYAHSLEFNM PVMSSETYPG WLTHWAENWA GRDISSTVSE
FENLVKNKHS FSMYMVFGGS NFGLTAGSNN DNSDTAFQPD ITSYDYDAPI NEQGAPTDKF
YALREMFKSH FNWTIPNVPQ IQNLTTVDQF TPQRLGSLRL LYNSLPKVTF QQAQSFEVLN
QNQGIVVYTF QVPISNSPQN TNYTLSFDKI RDFAKVYVQV NNSTTYNGTI NRMNQQNSFS
FSYSGNATNA TVTIFVEAFG HVNYGHTSFD NKGIIGNIYF QNKNISNISH TLIPLQNIPN
IIPSPSAVDS QNSETFFKGT FKINGQIGDT YLNMSNYTKG YVWVNGFNLG RYWNIGPQQK
LFCPATILKQ NNEIVILDLI QNTAAPIKGE LTLH
//
