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Database: UniProt
Entry: Q23AP2_TETTS
LinkDB: Q23AP2_TETTS
Original site: Q23AP2_TETTS 
ID   Q23AP2_TETTS            Unreviewed;      1100 AA.
AC   Q23AP2;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   25-OCT-2017, entry version 67.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR93650.2};
GN   ORFNames=TTHERM_00772070 {ECO:0000313|EMBL:EAR93650.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93650.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662723; EAR93650.2; -; Genomic_DNA.
DR   RefSeq; XP_001013895.2; XM_001013895.2.
DR   STRING; 5911.EAR93650; -.
DR   EnsemblProtists; EAR93650; EAR93650; TTHERM_00772070.
DR   GeneID; 7825552; -.
DR   KEGG; tet:TTHERM_00772070; -.
DR   InParanoid; Q23AP2; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    318    338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    354    373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    394    413       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    419    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    459    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    504    524       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    531    552       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      642    752       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1100 AA;  129542 MW;  FB2CEC2DF9C1EA75 CRC64;
     MKLKSLDENR AYQKRKTIKK EKSLFDFTPR LAIPEFTIPS IRQNDDDIQI SLDCSERHTL
     DMNGDQTVSD HKLKKSASFM SKNTTKNNIS FNNRSDNNIL IHQDQEGFMK QQNDQNMDLY
     SKVDFISEKN IALSIAGGSQ RNIPISATKI QKQLANRRQS KFYFSESESR FKIPSQNSRE
     YKVENIENLP RLKSNFSLIS NIKGNLNKMQ QKVIAIGMLL VFYVKLKTLS GVNQITKQYM
     LSSKVDNKSH QLKCLTYLND FSQISDKKQQ QLKKENNLIS LSTINNQKNE SGQQNKKCSF
     IQFCFGCIPV IHPDSKKLFL FDIINLIFII LNLTYVPIET VIDTPFLQMY GNKWFIFITS
     SISVYFFSVI LSLNMGYYDK GYCIMDRNKI LVRYMKLGFW VDILSTFPMF VSGINSKPVY
     KMCNLFVILK INWIDKFFYK YFEICNLKKK IKKMVFLKFL YILLKILFFV HVFACVFLAF
     SYHVNATDNW ITKYGSDLDS KGWFTKYVYA FYWGITIMTT VGLGDILPSN IYEVCVLSLF
     MFFSCAAFAY SFNSIGIILD EMNQRSDLFV KEMRIVSRYL QMKKVDHELQ IEVRKYIEYR
     FQFENEISQE EEKIVFKRLP ISIQEKLIIQ SNMAILRKIS FLQNNFSEGL LNKLCLTIES
     EQWLNQDTIY KQDDVYAESS NSIKFYILES GQVQLLANAG NPDQPLVIKN ITDVEDFGSL
     EFFNDEPRHY TAVTIGTTKL LSISRSKFLQ ILKQFPEDYE KFKMLCENAK MNKIQFDIKI
     SCYCCQKYNH SLKECPKIHY IANKELSILK NMFSLPQQRK ASRRNFKLKI NSLYENHIIQ
     ERAICYQQYN HDELNKIESP LITQEDILNT ETYRNGNGNI HKNQNNQKVL LNIATNDLIS
     RVDFDIQEKN LNKLVRNQSF STRKSTCLRP TLFKQNTDAI NIDQNEDILK QQVESNYSPV
     SLSQRKHHTT INLNTHDQQL FHKNQKKNTE SPSPHISYQK RHISINNLPQ DEINEKDISF
     MIDNFDRLKN YKYYFPYNNY DNILNQYEKI RPKFKYQRLR KPSQYFLFPN LNFKKLTKNT
     KNKIQSENKI DVTFNDSFNA
//
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