ID Q23AQ0_TETTS Unreviewed; 673 AA.
AC Q23AQ0;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 3.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:EAR93642.3};
GN ORFNames=TTHERM_00771980 {ECO:0000313|EMBL:EAR93642.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93642.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000256|ARBA:ARBA00005348}.
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DR EMBL; GG662723; EAR93642.3; -; Genomic_DNA.
DR RefSeq; XP_001013887.3; XM_001013887.3.
DR AlphaFoldDB; Q23AQ0; -.
DR STRING; 312017.Q23AQ0; -.
DR EnsemblProtists; EAR93642; EAR93642; TTHERM_00771980.
DR GeneID; 7825544; -.
DR KEGG; tet:TTHERM_00771980; -.
DR eggNOG; KOG1125; Eukaryota.
DR HOGENOM; CLU_441778_0_0_1; -.
DR InParanoid; Q23AQ0; -.
DR OrthoDB; 2020042at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130:SF0; GH08708P; 1.
DR PANTHER; PTHR10130; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5; 1.
DR Pfam; PF13414; TPR_11; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 497..530
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 531..564
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 565..598
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 141..188
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 673 AA; 78435 MW; 301C2553E2235820 CRC64;
MMRDILTGGA CNVNGESSSQ VNINPFNRLM GSLFMGNAQN QDRLQGFRTD GQQGDLMKNA
MQERAQMMQI MNQKFDMINK EEMANQQVMD QHFNQQQMLM HQQNLQMEQA FVQQQQMMHH
ENMMMDQMMQ EQFRQQQALQ IQQMQEQEKL MSQQFDSLKL QQEAEEYAQQ LMMENEMENV
ELEQQKIKHD AGELFDKMAK DDSPRMKNSK FLHFMGHLKS GQLKIEGNEI VEGVPDQDQK
DIDAIFNKAY ENAMEEQKQS ENNDGFNLEQ YWQQKISEYE KERQDEEGFE EKLDKEYQDV
LKYMQESGDY EELSKAWQKA SDLEEQSLYK DASGRYAFNK ANPYMSHENP LHLALEFIAS
GRPFDAILAL EAQIQKNPDA PSSANTWRLM GRLHQEMDQD QRAVACLLNA LQKDDRNPDT
FLALGVSCTN ILDEVKAMGF LKQWYLISDM QKAFPIPADI VPDDKVYSEL STDDIKNMNK
NMLDAFYAAR NQFPQNADLH VCLAVLQYIS RDYQGSVESF REALKYDPSN YSLWNKLGAT
LAQLGKADEA INAYYRALEL KPNYVRVWVN LGIAHAYKQD FDEAARLYLN ALSFNPEAKH
LWSYLQTCFM CLQRFDLVSK ISDHNPALFA DEFEILKFDD LPQPEFNYQE ATKKYLISEN
EINAMVSEQL NKK
//
