ID   Q23AR5_TETTS            Unreviewed;       635 AA.
AC   Q23AR5;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2007, sequence version 2.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=Integrin alpha FG-GAP repeat protein {ECO:0000313|EMBL:EAR93627.2};
GN   ORFNames=TTHERM_00770800 {ECO:0000313|EMBL:EAR93627.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR93627.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the TIP family. {ECO:0000256|ARBA:ARBA00006496}.
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DR   EMBL; GG662723; EAR93627.2; -; Genomic_DNA.
DR   RefSeq; XP_001013872.2; XM_001013872.3.
DR   AlphaFoldDB; Q23AR5; -.
DR   EnsemblProtists; EAR93627; EAR93627; TTHERM_00770800.
DR   GeneID; 7823116; -.
DR   KEGG; tet:TTHERM_00770800; -.
DR   eggNOG; KOG4550; Eukaryota.
DR   HOGENOM; CLU_020272_1_0_1; -.
DR   InParanoid; Q23AR5; -.
DR   OMA; PGDWIPW; -.
DR   OrthoDB; 5477979at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR024881; Tip.
DR   PANTHER; PTHR13412:SF0; T-CELL IMMUNOMODULATORY PROTEIN; 1.
DR   PANTHER; PTHR13412; T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG; 1.
DR   Pfam; PF13517; FG-GAP_3; 2.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Integrin {ECO:0000313|EMBL:EAR93627.2}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..635
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004201725"
FT   TRANSMEM        593..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   635 AA;  71525 MW;  3BD1D556B5A2D03C CRC64;
     MIKIHKVLSI ALVISVIFSG VLALKNANDF KSSLFKFNSI PSGVYEIEIG DYFTNRILMA
     YGDYNGDKYT DMITVTSLQN PGSSQTISVN LWSTQDGRFV EYDLPVPKCK GAIKNIIPGD
     INFDGQLDMV VVTAQGNGQF CLDFFKQNNC MMSGCPFESL DFSATFNPIQ MKSQPIAGDF
     TGQHFFQLMI YNSLTQKREI FEFQPDRIVN VHFLDLYSKD DNCQDYPNQF DFSVPHFSSV
     VDFNGDCRAD LVIQTQQGIE FWAKDDNKNF CLVAIQQMKR AGASIVSFTF ADVNFDGSID
     MVALVQDNGY RIVTMYNKFR VSASNLCSKF KQYPYELISS PSSYVQYQDE TIDVYSNNQG
     YLPVQIRMGD INWDGQPDII ITTNTAGANY GQPIILTNSD CNDSDCANLS VSNKRQFLPS
     TSSNFNSLYK TQAINIAFFD INEDGKLDFM VNTFENGMYS IRCFFNYIQN DAFFLKALGL
     NGQCTTSSCQ SSVYYGASYQ CKVTTLDTQY KTATGAQLTQ SANGALQLPF VILGLSRTNN
     YIENFSVGLS QPDADTSTRS WTPIIPNSQL IIFPYTLDPS KWEISIFVQP NDALIIVIIV
     TVIILAILGS IIIYYRRQEI NQDTQNQEEF LKMIR
//