ID Q23EE3_TETTS Unreviewed; 540 AA.
AC Q23EE3;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=malate dehydrogenase {ECO:0000256|ARBA:ARBA00012995};
DE EC=1.1.1.37 {ECO:0000256|ARBA:ARBA00012995};
GN ORFNames=TTHERM_01029960 {ECO:0000313|EMBL:EAR94914.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR94914.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
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DR EMBL; GG662710; EAR94914.2; -; Genomic_DNA.
DR RefSeq; XP_001015159.2; XM_001015159.3.
DR AlphaFoldDB; Q23EE3; -.
DR STRING; 312017.Q23EE3; -.
DR EnsemblProtists; EAR94914; EAR94914; TTHERM_01029960.
DR GeneID; 7824839; -.
DR KEGG; tet:TTHERM_01029960; -.
DR eggNOG; KOG1496; Eukaryota.
DR HOGENOM; CLU_040727_2_0_1; -.
DR InParanoid; Q23EE3; -.
DR OrthoDB; 501358at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR CDD; cd01336; MDH_cytoplasmic_cytosolic; 1.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR001252; Malate_DH_AS.
DR InterPro; IPR011274; Malate_DH_NAD-dep_euk.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01759; MalateDH-SF1; 1.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF3; MALATE DEHYDROGENASE, CYTOPLASMIC; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00068; MDH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 211..357
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 361..527
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
SQ SEQUENCE 540 AA; 62336 MW; 732F7BD91AB99A51 CRC64;
MIKEYFFQNY YLFQFIPKKT QINGMIQKQL FLVEYVRQEG YKIFIILYAN MQPSFFFRNQ
DSINVKHFRH IKHAYAYLHT GCVYLQSVKG LAPTKIERVI QVQRESYYDQ VIYHDPNQKS
NKKVINQISK DKRKNKQTNI RIYQKIKKER KLVQLLLFDN LISGTQLFLE IKEKNNQLIC
KNIQKKLKVF IIFKKNIKHI LEVMENKAVI NVCITGAAGN IAYALYSILC TGQIFGSNQK
MNLKLLDIES QAKGLQGVAL ELEDCAYALV NSIEYGFDPE VLFKDMDVGI FLGGQSRRPG
MERVDLLQVN NRIFKIQGKA LNKVAKPSTK ILVIANPVNT NCLTLIQNCP NIPKENFTCL
TRLDHNRAIA QLAIKAKVPV TEVKNVILWG NHSLTMYPDH NHAHIEGQPA VDIYEEEWIK
NTFIPKVQKR GGEVLNLRQN SSVMSAAIAI RDHLVNWIYG TPEGQFVSMG VYTDGSFYDI
PADFVFSVPV KCKDFKYEVV KDLTISQFSR QKINISLREL QDEKEEANCY DDDAEDESEE
//