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Database: UniProt
Entry: Q23F97_TETTS
LinkDB: Q23F97_TETTS
Original site: Q23F97_TETTS 
ID   Q23F97_TETTS            Unreviewed;      1121 AA.
AC   Q23F97;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   07-JUN-2017, entry version 59.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAR95256.3};
GN   ORFNames=TTHERM_00382170 {ECO:0000313|EMBL:EAR95256.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR95256.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662706; EAR95256.3; -; Genomic_DNA.
DR   RefSeq; XP_001015501.3; XM_001015501.3.
DR   EnsemblProtists; EAR95256; EAR95256; TTHERM_00382170.
DR   GeneID; 7835559; -.
DR   KEGG; tet:TTHERM_00382170; -.
DR   InParanoid; Q23F97; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    282    306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    321    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    367    394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    422    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    472    491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    497    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      603    708       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1121 AA;  131983 MW;  555AB9265648D05D CRC64;
     MSNKQLQHQN SFEQNYQQGA QKRSLWTLNV RQQKINMDDY IYSSQSIQSN MNIKSNNNHL
     ESNSFSKDTS QVDLSQIVTD SYNSKRQQNF VQGQSQDNKI YVSQQLGSTI QDKQNQKSQS
     ESLYEQKTII IQNEKKEQVI HEQDDCTSIY SKKLTSKQNI EDSVNKGQCL FERLGIKGKL
     TLSQSLALFF NIHRFVKKVK STENNNFRNL TLSQHKYIND ISSNYSYFLH NNKFRMTPTF
     FEQWKYKISQ LDLTKRLSSS CLGRLLIKFA KKLDFVILPN STFYTVFSVI MFVVILRIII
     FIPIFLSQQE ITEKDYEGSS YIWFNILSCL CFCLEILFKL NTAIYIRGEL ICRRRKIFKH
     LMKSKQLILD IFLTTIIIFI SAYQMNYISF LLLLKVKDLQ QTLMQLELKY QLKGNLQALI
     EMIKLIFVIL FMAHIVACGA MFIQKIEISL GNNNAWFASH LSESWLDKYI NAFYWSIVTM
     VTLGYGDIVP ITLNEKLYAI GVALVGCFIL SYSMNQVGEI LNGLAKSSTL FKEKLQQLNN
     YFSKNYIERD LQLKVIKYYE YLQYEDQECI NEGYKLIHQL PDQLKKEIQS KLYQNLFLNK
     KFFSLNFSKE FLHSLSLKIQ EDVLHPRQVL YQKNEYPQRL YFILNGKIEI FFDATDKKKS
     FQVRKIKNKG EMIGEVEFFS NYQYELSAKS MSVANLAFIE KEDFLQELYK YPTDYEKFKM
     IQDQLCFKLY QKTGFMCQSC FSFKHRLNQC PYILYQSPKE RIISLHLKSQ GVNHRQSFQR
     TKLKSANTRS ILMVIKQDAE ILVQSLLFSQ NEIILSKGDV QQQTQKPFTS SLNCNSSNYI
     GTKGKKRKES QNLTIYLNED PHQITRRKMK AKLTCIMNQV DSANEGLNKI PKNNNFQSQA
     LLKYQESELT SSKGILPEND NNQFFSQYQQ QKEQADIQIE EKDETSINSK LIEQNLGSQN
     CKLEEQQIYK KRKVSYQYND DKPIYQTQDD QKTSLKIIET NKQTSNNILS QIIIENSQRT
     LLFEQETLNE QLTKQISIQH FDLIHFDQGK DYLIYFPHNN LTKVLAQIDQ IRKQKMQNIL
     KAKVKKQNTK KIGKIEHRKR KSVFKQIKIE SFSLQRDKKQ I
//
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