ID   Q23RK8_TETTS            Unreviewed;       830 AA.
AC   Q23RK8;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 3.
DT   22-FEB-2023, entry version 65.
DE   SubName: Full=PX domain protein {ECO:0000313|EMBL:EAR99040.3};
GN   ORFNames=TTHERM_00384840 {ECO:0000313|EMBL:EAR99040.3};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99040.3, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662644; EAR99040.3; -; Genomic_DNA.
DR   RefSeq; XP_001019285.3; XM_001019285.3.
DR   AlphaFoldDB; Q23RK8; -.
DR   EnsemblProtists; EAR99040; EAR99040; TTHERM_00384840.
DR   GeneID; 7822888; -.
DR   KEGG; tet:TTHERM_00384840; -.
DR   eggNOG; ENOG502SVS6; Eukaryota.
DR   HOGENOM; CLU_352165_0_0_1; -.
DR   InParanoid; Q23RK8; -.
DR   OrthoDB; 5679239at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 2.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   SUPFAM; SSF64268; PX domain; 3.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          275..390
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   830 AA;  98801 MW;  8063DDC5F81A9C39 CRC64;
     MVEFIENSDD PSSPSFDKAS YLANEFFFSM VPCYVFLITA VIRYFRVKDK PKKYHEYVFE
     DTLVSFQIKL RISQFMAFTY LVSLVLGLVS PALLFFGAQF GWINFLYIFG IIAWIVSVEL
     LKFEYVREQN QGLYGHRVFW IFSFCFNVLR LFQSHMALFN IIISVSRSIP NFVLLMYGMY
     KPFDKASQEF DEETPTFARL FFEKFENNRI ISKILWYTIV DRSKQSSIHQ HLIEDIEMKD
     QPNGFAVFEI TENEDFEVTQ SSIDQERKLF NFLPRRNVTV SLKSETRIEE GQQKVYYQVI
     TTIDNNPYSV FKRFNEFSLV CADLSEIYDH KNYPKLDKNF PILVKDDFKD KDREKKRIQA
     IQNWLNEVFK YPFFMHKILL DFLNVEQKLQ NPFIVYFKHV SVMKGNKNPI LEKQKKEQEK
     QVNKTNTTNQ DYGVNYDDHF MYLEKQTRLL RNNSTVQDLL HVSKIIKARK DQYNFEISCK
     NAEKSQYGNT LQYLFEVTFI PKQGQKQRWT ISKTFTELRE LNDQIQEELQ INVTYYSSIQ
     SIMKIKDSTD KQDIKKKVEA VNQYMQSILK QKSFFCKPLF DFIEFDPQKE IHYNSRMCTP
     RQTILNSENE AMIAQMQGSS TLSQYQGITD EREPGLKTQY NSGLKGVNLL KEFNLINESD
     FQRNQQILEL RDNSKERFVY GINLNRVIIS VQKIMTKQIQ SAQFKNETRL VTQYLIHLEE
     YDSFGVIIKQ IKLLKYYNQI KQLDENLKYV YRNVDMNYPQ IPYDRTPSNQ FIADEMKKEF
     DLYFEGILKL SFVEENSSFE GFFHLKELIN VRKISQTGII TYDFSLNDEN
//