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Database: UniProt
Entry: Q23ZH4_TETTS
LinkDB: Q23ZH4_TETTS
Original site: Q23ZH4_TETTS 
ID   Q23ZH4_TETTS            Unreviewed;      2948 AA.
AC   Q23ZH4;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   05-JUL-2017, entry version 72.
DE   SubName: Full=Cation channel family transporter {ECO:0000313|EMBL:EAS01883.2};
GN   ORFNames=TTHERM_00785900 {ECO:0000313|EMBL:EAS01883.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS01883.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662552; EAS01883.2; -; Genomic_DNA.
DR   RefSeq; XP_001022128.2; XM_001022128.2.
DR   STRING; 5911.EAS01883; -.
DR   PRIDE; Q23ZH4; -.
DR   EnsemblProtists; EAS01883; EAS01883; TTHERM_00785900.
DR   GeneID; 7831175; -.
DR   KEGG; tet:TTHERM_00785900; -.
DR   InParanoid; Q23ZH4; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    221    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    256    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    335       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    417    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1619   1637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1649   1673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1679   1697       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1742   1764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1820   1841       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1999   2018       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2038   2060       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2072   2097       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2117   2146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2197   2216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2236   2261       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2319   2338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2350   2372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2384   2402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2451   2473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2523   2545       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      188    455       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1613   1850       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1998   2269       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2319   2551       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       71    117       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2948 AA;  341330 MW;  23DBF5B3728AFC95 CRC64;
     MNSYVVEANW IRRLRQVLKQ EIPEETEEDK TFKRIEKAKA GKEKKSQIDN FNNKNQDISD
     DSSNSSSSFD LNNLVEENEN QRNAYMKVAN AFLEQDSDKS DNEIQKLNKE NEQRLQKKIE
     NHYEQEFETE FQINKLSIDN NPVLDVVEMN VFDRIALFQA VTIFEKIYKQ VWYIKEKISY
     ICFCIINHNI FTVISLSVII FNSVMLARDD PTTNSDNNPA IDLSLLVIYT VEMGLKILAM
     GFIFSKNSYL SEGWNVLDFV IIVTGWLPYV INSSSFNLTA LRSLRVLRPL RSISKVKILN
     QLVTALFTAI PLLKDAFIIL CFFFGVFGIA GLQLFSGQLK TRCIDIYTGI KLGDENNNLF
     VCAQDGDCPI QQGISYICAK GMVSPNSDLY NFDTFGWSLL NVYVVVSNEG WSTIMQFVMV
     GFNFFAFIYF FLIVYLGTWL LVNLCMGIIA VKYSESIANQ SIQSSIKGNQ EGYNMQNLIR
     WGIYKSNKIL YKELDEQKKK KKNWFDLSFS MSSLLASYKR KSQKFETPQL QGIGSQEQHH
     LKHSKILPLD LNTQTESKIY PKTENDQKIN QNEQTPKINL IEKTPINENQ QEEQNKNSDE
     KNSVNKKQAV LNGNDNRSNG NSTPLSAKVQ LSLGIIRQNS NLNQLNEDAK NSNKKQYEHS
     KYKSDKQKTK LIVQTTEKKT LNGIVDPSIL ANKLEFIKTE QIQQKKTSKK LISASKDMHP
     KVESSFQRYY ELQNQKMDQK KLNFAPIQKQ KPQQQEQKPS LNKIQAAHKE TNEGQQISRK
     KSKNGHEIRR ASKKLNNMFQ FQENFKEEEE ESDEDFLMQI ENCKEFNNQN GINQNDDQQI
     EENYLNQIHN TLAFQSLKQK KLEKKKQHDP NLENKKRENN EIAMYSHSQD SKVKKNSENR
     SSSLNIQKKK DFTFKRGTKE ISNSNNTNKM SQNTETNSNE ESLSDISEMS FLVQEDQEQE
     RNVKPQLNRK STMLNNMFNE LEIQVLKNKK LNFENKQKNV QGQGHRKSTK NVKQVTEKYE
     SLLSQETNNI EQQLQSKINK QIDQKAEDFR LLLDTKYLKP RVIYAETNDY TPEILPTKLQ
     KQTELFLKSQ DEKMKGMRFR LKQQSSLVFK KEKAQKKLQF KLPFSKSKRV EVLQEDLILD
     AMLAGKFTTD NQSIKYSKQA DQKNDLQSYD SPNPFRQTKM SGFMQKTTLN KAFSSKEEEK
     NSVALYSQPK QLMPFSPNIN AKQIFLKQQF NFESNIQSQV DDKKAQSIVS KQDNNYQKDL
     NNSINQDLDA LNSPSNQAKS VKDYSEIKDS PRKDGKKEIF INGGEDKNDK SVRSSKNVSI
     VQSNEQDQQN FTSRMQSLRN RNDSNQSNQD QLNSSLRSKI IAKPTDKKLN TSGAIFQQKK
     GKNQKGDEVE NQWDIQKAIQ KIFTDQTELE KDEQQQQQDD QDQKQTNLKG QKTQVQSTKA
     QQQKNTYDVM MYQLEQKIIK KAERQLDILN KSPSIQAPQA DNKSVKSVDT VLTTQNSMND
     ENDANSTQKN IFQNQQVEAF DFEQFQQESA EYKYLQQRKK DIQNFEKKGI CELKVQTSAD
     DVLSISLKYK QQDALSKVLD TINCRQDIIE QNEGGIIGII QAIRRRVKGF VMHPVFENLI
     MLCVLLNTVV LCMDGIIPTS SAYILDTFNL IFTILFAIDM GLKIIGMGLV MYASDKMNIF
     DAVIVSLSIF ELIFLNGTSS VSALRSIRIL RVFRVLRVTR LLRSLQFMKI LVTAISSTLE
     QFIYILLLLF LIMFIYALLG MSLFGGNWPV YNSNIPSRLN YDQFINAAFA VLDLLTLENW
     NDQLTNCLIS NVSNYVCTAY LISMIFIGNY ILLGLVLAIM LDSFNSAEVQ NDRQEIENRF
     EIVQDLTFGH TSMGTTFMNN LSQSMGNQSS NNMSRISGGI QQSGGLQRSA TLSRQVINKL
     SQSNDSGQLD KSKSIIGGDD HSSSDRVTSI NSESKLKQDN KKNKNKFIWF EGVECEKSLF
     LFSKEGNFRK SIYYIYKHAM FEKIVLLIII LTSFKLTFDT YIGTADVTAT QFSNDADLFF
     TIFFLCECLI KVIALGFILD EGSYLRDNWC QLDFFIVVSS LVDLSLSSVN LNAIKILRLL
     RTLRPLRLLS QNKSMKLIVT ALMESIGGIA NMIIVVLLIW LMFAILGLNL MQGKLFYCNT
     TGAALSGSYN VYNYPKKQCE QLPGAFWDRY PNNSDNIGFS MVMLFVLSTF EGWPNYVWYY
     LDGSDTGPVW NNSRYFGVFF TVFIFVGSFF SINLFTAIIS FNFDIATKKA KNAFLTDDQS
     QWIELQRLIV KSTPDYASMK PPDNNFRKIL WRISESPKLD IFIIFCIIGN VVVMAMAYDT
     SSSNYDFILQ SVNLGFTGVF IAECIIKIIA YGIQGYFYKG WNQFDFFVVC ASVVDIIMSY
     SGKSFFSFLK AGPQIARVLR VLRVSRLLKL IKSFQGLQKL IQTTVFAFPK FLNATLLFVL
     FYFIFSILAW FLFSDLQSGW RLSTFWNFTN FHRAIILLVR MSTGEDWYLV MYDTFNAKGV
     IGLIFFVSFY TVQSYILMNL FVLIIMNEFE ENYINPDNPL SNFNEQEEQF KKRWVQMTQK
     DSGIKIHEKY LTEFYFELPA PLGFDFLRKS EDFVDQIKSR DNSITHEEIQ SRLDRFRIRQ
     RQEADKNIMK MNVFCDYEGY IYFNDLFYQL FKFSLYSSVY ELDVNSQEDP KALQRHNTAL
     EILKKEEKVT WKKIGIIKKK QSSLLKAKIV LQRQQGVNPM VRRLFVGMAF KSWLQYSIRT
     QDNLNQINFN KDDISSQTDS ENSQDENNEQ IDNFYLDESF EDGIQFKKQK PGIIKREHTI
     TFRPGGLKKY RDEHEKQQQI KQNKKYHRLP NVDVYQQDCY DEKNAKYFEV DEDDVYVETK
     HYIQEETGRK SILQRPSILF ANPLQPRKSV LHTLVSEKDN SDVRKSINQK YQNIMKENAI
     LESDNEQK
//
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