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Database: UniProt
Entry: Q248C6_TETTS
LinkDB: Q248C6_TETTS
Original site: Q248C6_TETTS 
ID   Q248C6_TETTS            Unreviewed;      1143 AA.
AC   Q248C6;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 2.
DT   27-SEP-2017, entry version 59.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EAS04119.2};
GN   ORFNames=TTHERM_00532410 {ECO:0000313|EMBL:EAS04119.2};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS04119.2, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662455; EAS04119.2; -; Genomic_DNA.
DR   RefSeq; XP_001024364.2; XM_001024364.2.
DR   STRING; 5911.EAS04119; -.
DR   EnsemblProtists; EAS04119; EAS04119; TTHERM_00532410.
DR   GeneID; 7840782; -.
DR   KEGG; tet:TTHERM_00532410; -.
DR   InParanoid; Q248C6; -.
DR   KO; K21867; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    318    334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    355    372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    528    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      631    734       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      979   1002       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1143 AA;  135448 MW;  8E3ADEE242D92959 CRC64;
     MITDQAKICS ESMSQTIQFG SNSLALRLEN SNEDDNADMR RGSVFRRAYY EKQNSCNGFN
     KINMRKEDDS QELDSQQLYQ DQPSRNSPQQ NQKPKEIKES QICNTKTIQY FKENDTEFDQ
     VHFSQNVEFL NNSSRSIQSS LGNENIQQKN TLQNQDKNML HIHTNYFEEN TENVTNTQYE
     NFSQFLHKNQ INLLKYNNRQ IETYENSQSS QTNKSLNIHN IIIQYQKNRK ETKGETENMD
     QTVVIYKSNF LKRIYFVLKF LKKIKFNVLF RSIGHIQNGF SDLIDDQASH FDSTKDKPYL
     LLKLEYILSK IQVFQQDSFG IIIWEFIQFI TILLQSTWIP MNKIFHIKQQ NFDDSLFQFS
     SIIFSFSILV RFNTSVYFQG NLAIDRKEIA KRYLKTSFML DFSTTFILII SSYINDSTVL
     PLVILRLYQL PSIEKKIKTA LIMRQKMFKA EYELIKLIGL LLLVAHFIAC GFFYVGTTGL
     GEENWINKNN LQNKEWTIQY LNSIYFSVIT MITIGYGDIT PISPQEKIYV MSITFIGSGL
     FAYSINAIGE IIRSNFQEQE SFLIQQQDVL NYLQKRQISK QLMLKVIKQL EYINKHEKYQ
     RGEYALQKLN EPLQNEVKTQ FYGKIIKSNK LFSKLFSTQF LNKMSLIMKD VQLYPNEVVI
     KKGEVSNKIF FIYRGQINQV FERDLNDHTI YALKAGSLIN LRQFILQKQS DNTFKSANIC
     TVVYCEYNQF KDLLSSFKED HETFYKLKDI LLQDISNDAC QEQRCSCCNQ FSHQTYKCSC
     LSFVPQKDVI IKRYIFPFVQ TRDHSYRRKT THNKTLQHLN EFKTSLKEFR IFKILQEQKE
     DIEQIFQYGD IQSLYECEDY YFYQRVPIIK NVCYEDQIKL SGIDQEEDNT FRERNNQNSL
     TSVEQSIIVN SQSMSIQNQK YKQQSKQEES QIETFNNKIR ISSRFLSYYE NIKQNNKDVT
     TSQETEKDYD QSPLIKNNID QEQKKLKQNQ NVDEELQNKQ KNVDFGISQL NQELKLPIQS
     SQQLVKYQQS INKVNSPKGN NRIMIQEISN LERKINVQNQ INQEDDIETL DVFVNYFDKM
     KEYKIYFPHN NYNLVISSFK KAYSNQQKQK QQQFKRRQSN KFRQFSKNTS TTFRNNNHLS
     NIS
//
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