ID Q24F62_TETTS Unreviewed; 423 AA.
AC Q24F62;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE SubName: Full=Eukaryotic aspartyl protease family protein {ECO:0000313|EMBL:EAS06413.1};
GN ORFNames=TTHERM_01128640 {ECO:0000313|EMBL:EAS06413.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS06413.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; GG662295; EAS06413.1; -; Genomic_DNA.
DR RefSeq; XP_001026658.1; XM_001026658.1.
DR AlphaFoldDB; Q24F62; -.
DR STRING; 312017.Q24F62; -.
DR EnsemblProtists; EAS06413; EAS06413; TTHERM_01128640.
DR GeneID; 7827977; -.
DR KEGG; tet:TTHERM_01128640; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_12_0_1; -.
DR InParanoid; Q24F62; -.
DR OMA; RCIALTI; -.
DR OrthoDB; 3087283at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:EAS06413.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..423
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004202239"
FT TRANSMEM 402..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..381
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 75
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 265
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ SEQUENCE 423 AA; 45454 MW; 36544B5EE1555D11 CRC64;
MNKTGSLILL LVAFNIAAAQ LVTIPIEKRV PESNNGFLDD NDQAAVDRLV NHNQYMYSGN
IEVGNSKQTY TVDFDTGSNL LWLTGKNCPT CVKDGYKHSY DCQVSDGCNM TSTPASITYG
DGSGVSGHIA KVPISIAGLA PVTEALLVVE KSVRNGGLES DGLMGLGVYD EHNTNAVPFV
NQLFKQGIIS KSQFSFYLGF GQNESELIIG GVDNTKLANP SQLYFHPIII NGQHNDSQRW
SVAIKSVSFG DQSVPLTSKN VAIVDSGTSL LVMRNDVFKQ WINYLKTVAT LKTITSGGSI
FYGVKCGATL PDLTFTLTDV NGVDRSYSLP SSFYVIQDNS SCIIGVQGIA LTSDVQFILG
DVFMRRFVSV FDYTTVSMGL AQSVANPAST NGSSSVNTLK TFIALGLVLI AVSALIILAL
RRK
//