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Database: UniProt
Entry: Q24F62_TETTS
LinkDB: Q24F62_TETTS
Original site: Q24F62_TETTS 
ID   Q24F62_TETTS            Unreviewed;       423 AA.
AC   Q24F62;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   24-JAN-2024, entry version 94.
DE   SubName: Full=Eukaryotic aspartyl protease family protein {ECO:0000313|EMBL:EAS06413.1};
GN   ORFNames=TTHERM_01128640 {ECO:0000313|EMBL:EAS06413.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS06413.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   EMBL; GG662295; EAS06413.1; -; Genomic_DNA.
DR   RefSeq; XP_001026658.1; XM_001026658.1.
DR   AlphaFoldDB; Q24F62; -.
DR   STRING; 312017.Q24F62; -.
DR   EnsemblProtists; EAS06413; EAS06413; TTHERM_01128640.
DR   GeneID; 7827977; -.
DR   KEGG; tet:TTHERM_01128640; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   HOGENOM; CLU_013253_12_0_1; -.
DR   InParanoid; Q24F62; -.
DR   OMA; RCIALTI; -.
DR   OrthoDB; 3087283at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:EAS06413.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..423
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004202239"
FT   TRANSMEM        402..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          57..381
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        75
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        265
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ   SEQUENCE   423 AA;  45454 MW;  36544B5EE1555D11 CRC64;
     MNKTGSLILL LVAFNIAAAQ LVTIPIEKRV PESNNGFLDD NDQAAVDRLV NHNQYMYSGN
     IEVGNSKQTY TVDFDTGSNL LWLTGKNCPT CVKDGYKHSY DCQVSDGCNM TSTPASITYG
     DGSGVSGHIA KVPISIAGLA PVTEALLVVE KSVRNGGLES DGLMGLGVYD EHNTNAVPFV
     NQLFKQGIIS KSQFSFYLGF GQNESELIIG GVDNTKLANP SQLYFHPIII NGQHNDSQRW
     SVAIKSVSFG DQSVPLTSKN VAIVDSGTSL LVMRNDVFKQ WINYLKTVAT LKTITSGGSI
     FYGVKCGATL PDLTFTLTDV NGVDRSYSLP SSFYVIQDNS SCIIGVQGIA LTSDVQFILG
     DVFMRRFVSV FDYTTVSMGL AQSVANPAST NGSSSVNTLK TFIALGLVLI AVSALIILAL
     RRK
//
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