ID Q24I84_TETTS Unreviewed; 427 AA.
AC Q24I84;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=ATP-dependent protease LA (LON) domain protein {ECO:0000313|EMBL:EAS07513.2};
GN ORFNames=TTHERM_01035760 {ECO:0000313|EMBL:EAS07513.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS07513.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662225; EAS07513.2; -; Genomic_DNA.
DR RefSeq; XP_001027755.2; XM_001027755.2.
DR AlphaFoldDB; Q24I84; -.
DR STRING; 312017.Q24I84; -.
DR EnsemblProtists; EAS07513; EAS07513; TTHERM_01035760.
DR GeneID; 7837651; -.
DR KEGG; tet:TTHERM_01035760; -.
DR HOGENOM; CLU_740784_0_0_1; -.
DR InParanoid; Q24I84; -.
DR OrthoDB; 3088759at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327:SF42; LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C; 1.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EAS07513.2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:EAS07513.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 13..51
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 227..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 49194 MW; BD6636A75E190140 CRC64;
MSLNQTGVQV PECIICQDIF YQPVTLPCGH SYCRPCIKES LINKPLCPVC RNPMIGNPDN
LSINFTLQNI IEHHHSELYQ QKVNSIKKKV NLGQQQNSGL NNVNLEGNNQ QKQEQKLENI
LLLQEFKMKY LFPCTTVDVN LKYIHQLQQL LVQCSDKRVI ILFAKNDEQV AAYCQIIQIY
NPDQINNQKS PSSIKCQVKV LSKASILDVK EVKINYSEAT NLQQDQAQSL EQQNQNNQTN
NQNESTQSGT HQNQRIFEDG YTFKVANAKV IEDQTIPQDQ QVGLEEHAEF VIQIINEIVQ
NNGGLNMTTY QLQAFLQQQN FLPFLQHGYI DSVSKINEFC WIICEIFNFN ISEKQRLWDA
ESIIERLALI KQFIKKFEKI YNITSVFSIE APGHSEHLTW IIFGIIALVV IAKLSKEYFG
IQFINHI
//
