ID   Q24NG7_DESHY            Unreviewed;       594 AA.
AC   Q24NG7;
DT   18-APR-2006, integrated into UniProtKB/TrEMBL.
DT   18-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=DSY4636 {ECO:0000313|EMBL:BAE86425.1};
OS   Desulfitobacterium hafniense (strain Y51).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC   Desulfitobacterium.
OX   NCBI_TaxID=138119 {ECO:0000313|EMBL:BAE86425.1, ECO:0000313|Proteomes:UP000001946};
RN   [1] {ECO:0000313|EMBL:BAE86425.1, ECO:0000313|Proteomes:UP000001946}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y51 {ECO:0000313|EMBL:BAE86425.1,
RC   ECO:0000313|Proteomes:UP000001946};
RX   PubMed=16513756; DOI=10.1128/JB.188.6.2262-2274.2006;
RA   Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K.,
RA   Inatomi K., Furukawa K., Inui M., Yukawa H.;
RT   "Complete genome sequence of the dehalorespiring bacterium
RT   Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides
RT   ethenogenes 195.";
RL   J. Bacteriol. 188:2262-2274(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; AP008230; BAE86425.1; -; Genomic_DNA.
DR   RefSeq; WP_011461993.1; NC_007907.1.
DR   AlphaFoldDB; Q24NG7; -.
DR   STRING; 138119.DSY4636; -.
DR   KEGG; dsy:DSY4636; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_8_3_9; -.
DR   Proteomes; UP000001946; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF3; ATP-DEPENDENT HELICASE_DEOXYRIBONUCLEASE SUBUNIT B; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001946}.
FT   DOMAIN          5..296
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         26..33
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   594 AA;  67542 MW;  637E5F4316063055 CRC64;
     MHNEEIEIIT SDHLLSDVDH PFKVFAGPGA GKTFWLINNI KNILKNSTRL FSASKISCIT
     YTNVAVEEIQ TRLDMTGDRV EVSTIHSFLY NCLVKPYVNL LKYEDGSYLV NIEQLDGHDD
     HIPSVGRILG NKQMSATVLK NRIDHKELQG VLSSLDWYLN GDDLILQPRN DWQRKKYKKL
     VTAGFFNAYK AMFWDDGTIH HEDVLFFSHE ILKNHPLIRE FIAAKYPYIL IDEFQDTHPV
     QTKILKWISE AGAIIGVIGD PAQSIFKFQG ASRADFLEFK LPGQKNYAIK YNRRSTRNIV
     NILNHIRGTD EVVQECYREI DGSEVCIIVN KSVEGIIEKF NSERARLGMT GDSCIVTRRN
     DSVVKLKNCA GNCNMSIWSD FSEADSKRQR FIEVILSAQE YADNSMHETA VKQVMKVFKT
     DKEGALKDPF TACSFEIDNL SKRSMAVSLL EYLTSNRDEN MTKNVLAFYN DLIGFFNGIG
     VALKRVGAGG FKTFAQAANV NELVLSLKLG EEKYSNIRTI HKSKGAEFQS ILVYFEDNKD
     IQHLLNPDAK HEEDDCRLYY VALSRAEDYL CIATDELSQE IIDALAKLNL KMIG
//