ID Q25377_DOROP Unreviewed; 1784 AA.
AC Q25377;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Doryteuthis opalescens (California market squid) (Loligo opalescens).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC Coleoidea; Decapodiformes; Myopsida; Loliginidae; Doryteuthis.
OX NCBI_TaxID=1051066 {ECO:0000313|EMBL:AAA16202.1};
RN [1] {ECO:0000313|EMBL:AAA16202.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Stellate ganglia {ECO:0000313|EMBL:AAA16202.1};
RX PubMed=8234251; DOI=10.1073/pnas.90.21.10026;
RA Rosenthal J.J., Gilly W.F.;
RT "Amino acid sequence of a putative sodium channel expressed in the giant
RT axon of the squid Loligo opalescens.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:10026-10030(1993).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L19979; AAA16202.1; -; mRNA.
DR PIR; T43167; T43167.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:AAA16202.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 124..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 225..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 378..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 584..610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 622..641
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 661..682
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 703..731
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 751..771
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 792..816
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1024..1042
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1063..1082
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1094..1119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1140..1166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1261..1285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1346..1363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1375..1395
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1407..1425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1462..1487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1562..1585
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 131..411
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 593..820
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 827..1014
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1022..1293
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1345..1598
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 36..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1729..1784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1755..1770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1784 AA; 202533 MW; 74C4D7292EF2DCFB CRC64;
MATAKDLEKG DNPKGRFRLF TRETLFEIER RIAERRAQAE DADSDEEENE PELKPNPKFE
AGKGLPPSVE DVPSRYQGRP LEDLDEYYHN NKTFCVIGRD RTLYRFSATK AIFLLSPFNP
IRRFAIFILV HPIFSLVVIL TIVCNCVFMT MKENPLPVSE WIFTGIYTCE ALIKLFARGF
ILEPFTYLRD AWNWLDFVVI GLAYLTEVVD LGNLSALRTF RVLRALKTVA VIPGLKTIVG
ALLEAVRRLR DVMILTGFML SIFALIGMQL YQGALRSKCV RNNDENMTDS EYQKYVSIKA
NWQENFYGST LVCGNASGPG KCGENYTCLP EIMDNPNFGY TSFDNFAWAM LCAFRLMTQD
YWENLYQLVI RAEGPVHALF FILVIFLGSF YLVNLILAIV AMSYDEQQKQ DQADAEEEEA
ERKLEEENRI EEKSKEEMQI QSPSDYSIKS VELPAVTVDS AGKGEIVERM SIQSETGSEV
KRKLSVKLSG KSKRESISSG GSECETAKKK NYANNPFLCP SSSATNVVDM KDVMVLKDLI
DHASGARSSS VSSSESQPEL LKEKLIRIFC AWDCYPPFKT LRGYIGFFIM DAFVDLFITL
CIVLNTVFMA IDHYDMQEGL RVALEIGNYV FTAVFAAEAF LKILALAPQT YFKDPWNVFD
SFIVFLSLME LGLGGIQGLS VLRSFRLLRV FKLAKSWPTL NMLISIVAGT MGALGNLTLV
LGIIVFIFAV MGQQLFGANY EKPECFEDNQ VPRWGFRTFL HSFMIVFRVL CGEWIESMWT
CMEVAGYACV PFFLLTMIIG NLVVLNLFLA LLLSSFGAES LQSSKSDDEP NKLQEAIDRI
VRFTHWVKMS LLKCAKYKFK KKPINRPELP KVDINGKEII GDGHAIIGNG KFGDKIDDAV
TPTNQDATKE EKDVDVADGD TKLSESSTRL ASEVGDLKSP AGSHASSSLT SLSDGGEEDN
LKVQVDGEPE INEVDIVYVK TPDDCLCQFC NRNCNCWGYF QHTDFGKAWW KLRCFMYKVV
EHEYFETFII TMILASSLAL ALEDIHLRKK PILQLVLKYM DKCFTVIFIG EMFIKWFAFG
WKKYFTDAWC WLDFLIVAVS IIMLAAESIG MGNLTAFRSM RTLRALRPLR AVSRSEGMRV
VVNALIKAVP SIFNVLLVCL VFWLIFSIMG VQLFNGKFHK CVYNFNGTTV PATEVNNRSE
CEENPMLYKW KNSPINFDNV LNGYLALFQV ATFKGWINIM SDATDIRDIG DQPIKENSIL
MYLYFVLFII FGSFFTLNLF IGVIIDNFNQ QKKGAGGSLE VFMTDDQKKY YKAMKNLQSK
KPTKGIPMPG FKIAEWMFHL TTNQKFDVAI MMVILLNMIT MAMEHYNMSR TFEDFLKYIN
MVFIGIFTGE CVMKLMGLRF YYFKEPWNIF DFVVVVLSIL GIALSDIIKQ YFVSPTLLRV
VRVFRVGRVL RLVKSAKGIR TLLFSLAVSL PALFNIGLLL FLVMFIYSMF GMSFFMDVGY
FDGIDDVFNF QTLIQSMILL FQMSTSAGWD GVLAAIMREP PACQPDLKIF GSKSNNGNCG
NYGMAVMFLV TYLVISFLVV INMYIAVILE NFSQATEDVQ QGLTPDDFDM YYEKWEKFDP
KATQYIALSE LSDFVDFLEE PLQLPKPNHF MLVRLDIPIC EGERVHCVDI LAALTKNYLG
TLDDASAEGG AQPEAEKLDY NPISSTLRRQ KEHFAARIIQ RAWRRYRANR PHSSLPPPPS
YEESCKRQDE ITQEPNDKSP TGSATEVQTE VKTVELYPES GVVA
//
