ID ABDA_MANSE Reviewed; 97 AA.
AC Q26430;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Homeobox protein abdominal-A homolog;
DE Flags: Fragment;
GN Name=ABD-A;
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1685112; DOI=10.1242/dev.112.1.119;
RA Nagy L.M., Booker R., Riddiford L.M.;
RT "Isolation and embryonic expression of an abdominal-A-like gene from the
RT lepidopteran, Manduca sexta.";
RL Development 112:119-129(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Required for
CC segmental identity of the first through tenth abdominal segments.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; S77989; AAB21131.2; ALT_SEQ; Genomic_DNA.
DR PIR; A60127; A60127.
DR AlphaFoldDB; Q26430; -.
DR SMR; Q26430; -.
DR EnsemblMetazoa; XM_030165990.2; XP_030021850.2; LOC115441263.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR022132; Abdominal-A.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR PANTHER; PTHR45659:SF4; HOMEOTIC PROTEIN ULTRABITHORAX; 1.
DR Pfam; PF12407; Abdominal-A; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus.
FT CHAIN <1..>97
FT /note="Homeobox protein abdominal-A homolog"
FT /id="PRO_0000200252"
FT DNA_BIND 6..65
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 73..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 97
SQ SEQUENCE 97 AA; 12197 MW; 91C567E7C2CE8F6A CRC64;
SNGCPRRRGR QTYTRFQTLE LEKEFHFNHY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
LKKELRAVKE INEQARRERE EQDRMKQQQQ EKQAKLE
//
