ID LA_AEDAL Reviewed; 383 AA.
AC Q26457;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 01-MAY-2013, entry version 70.
DE RecName: Full=La protein homolog;
DE AltName: Full=La autoantigen homolog;
DE AltName: Full=La ribonucleoprotein;
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea;
OC Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=8551578;
RA Pardigon N., Strauss J.H.;
RT "Mosquito homolog of the La autoantigen binds to Sindbis virus RNA.";
RL J. Virol. 70:1173-1181(1996).
CC -!- FUNCTION: May be involved in transcription termination by RNA
CC polymerase III. Binds RNA and DNA. Binds to the 3' end of the
CC minus strand of Sindbis virus RNA. This may be significant for
CC Sindbis virus RNA replication.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Primarily nuclear,
CC but significant amounts are present in the cytoplasm.
CC -!- SIMILARITY: Contains 1 HTH La-type RNA-binding domain.
CC -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
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DR EMBL; S80954; AAB35931.1; -; mRNA.
DR ProteinModelPortal; Q26457; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030529; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR006630; Lupus_La_RNA-bd.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR InterPro; IPR014886; RRM_3.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF05383; La; 1.
DR Pfam; PF08777; RRM_3; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus;
KW RNA-binding.
FT CHAIN 1 383 La protein homolog.
FT /FTId=PRO_0000207605.
FT DOMAIN 37 129 HTH La-type RNA-binding.
FT DOMAIN 141 228 RRM.
SQ SEQUENCE 383 AA; 44430 MW; 4E5CC8F21C40F452 CRC64;
MTEVEAKATA TEETTKEEEE APETTAEQTE ESAQETSENV SKLEASTIRQ LEYYFGDANL
ARDKFLQEQI SKDEGWVPVD VLLTFKRLKS LSEDKKVIVD AIEKSDEGLI EVSEDREKLR
RHPERPLPEQ NEETRKEIYG RTVYVKGFAP EEGTQMSELL EFFEPFEKIT NIVMRKYHDK
ATKKYLFKGS VFVTFATKDH CAEFLKKEKL GYKGKELIRK MQDDYFEEKK AERRKKDKKK
EEDRFNIDHL PKGASVHLSG FNKDTSRETI KETILKLDES LEVAFIDYAK TDTEGTVRFA
ADDAGKKFME KLTDSKIQID EEEITARLLE GDEEKEFLRK VVKDQQARRQ ASNARNKGRT
PEGRQASRPP QEWRRKAKGG RGE
//
