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Database: UniProt
Entry: Q26457
LinkDB: Q26457
Original site: Q26457 
ID   LA_AEDAL                Reviewed;         383 AA.
AC   Q26457;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-OCT-2014, entry version 72.
DE   RecName: Full=La protein homolog;
DE   AltName: Full=La autoantigen homolog;
DE   AltName: Full=La ribonucleoprotein;
OS   Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=8551578;
RA   Pardigon N., Strauss J.H.;
RT   "Mosquito homolog of the La autoantigen binds to Sindbis virus RNA.";
RL   J. Virol. 70:1173-1181(1996).
CC   -!- FUNCTION: May be involved in transcription termination by RNA
CC       polymerase III. Binds RNA and DNA. Binds to the 3' end of the
CC       minus strand of Sindbis virus RNA. This may be significant for
CC       Sindbis virus RNA replication.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Primarily nuclear,
CC       but significant amounts are present in the cytoplasm.
CC   -!- SIMILARITY: Contains 1 HTH La-type RNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00332}.
CC   -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00176}.
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DR   EMBL; S80954; AAB35931.1; -; mRNA.
DR   ProteinModelPortal; Q26457; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0030529; C:ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002344; Lupus_La.
DR   InterPro; IPR006630; Lupus_La_RNA-bd.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR014886; RRM_3.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF05383; La; 1.
DR   Pfam; PF08777; RRM_3; 1.
DR   PRINTS; PR00302; LUPUSLA.
DR   SMART; SM00715; LA; 1.
DR   SMART; SM00360; RRM; 1.
DR   PROSITE; PS50961; HTH_LA; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus;
KW   RNA-binding.
FT   CHAIN         1    383       La protein homolog.
FT                                /FTId=PRO_0000207605.
FT   DOMAIN       37    129       HTH La-type RNA-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00332}.
FT   DOMAIN      141    228       RRM. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00176}.
SQ   SEQUENCE   383 AA;  44430 MW;  4E5CC8F21C40F452 CRC64;
     MTEVEAKATA TEETTKEEEE APETTAEQTE ESAQETSENV SKLEASTIRQ LEYYFGDANL
     ARDKFLQEQI SKDEGWVPVD VLLTFKRLKS LSEDKKVIVD AIEKSDEGLI EVSEDREKLR
     RHPERPLPEQ NEETRKEIYG RTVYVKGFAP EEGTQMSELL EFFEPFEKIT NIVMRKYHDK
     ATKKYLFKGS VFVTFATKDH CAEFLKKEKL GYKGKELIRK MQDDYFEEKK AERRKKDKKK
     EEDRFNIDHL PKGASVHLSG FNKDTSRETI KETILKLDES LEVAFIDYAK TDTEGTVRFA
     ADDAGKKFME KLTDSKIQID EEEITARLLE GDEEKEFLRK VVKDQQARRQ ASNARNKGRT
     PEGRQASRPP QEWRRKAKGG RGE
//
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