ID Q26965_TRYCR Unreviewed; 700 AA.
AC Q26965;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Trans-sialidase homolog {ECO:0000313|EMBL:BAA09335.1};
DE Flags: Fragment;
GN Name=TCTS-193 {ECO:0000313|EMBL:BAA09335.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:BAA09335.1};
RN [1] {ECO:0000313|EMBL:BAA09335.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000313|EMBL:BAA09335.1};
RX PubMed=8844669; DOI=10.1016/0166-6851(96)02634-5;
RA Smith L.E., Uemura H., Eichinger D.;
RT "Isolation and expression of an open reading frame encoding sialidase from
RT Trypanosoma rangeli.";
RL Mol. Biochem. Parasitol. 79:21-33(1996).
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DR EMBL; D50686; BAA09335.1; -; Genomic_DNA.
DR AlphaFoldDB; Q26965; -.
DR CAZy; GH33; Glycoside Hydrolase Family 33.
DR VEuPathDB; TriTrypDB:C3747_102g153; -.
DR VEuPathDB; TriTrypDB:ECC02_005196; -.
DR VEuPathDB; TriTrypDB:Tc_MARK_6952; -.
DR VEuPathDB; TriTrypDB:Tc_MARK_7299; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0150700; -.
DR VEuPathDB; TriTrypDB:TcCL_Unassigned04059; -.
DR VEuPathDB; TriTrypDB:TcCLB.509817.50; -.
DR VEuPathDB; TriTrypDB:TCDM_10018; -.
DR VEuPathDB; TriTrypDB:TcG_09199; -.
DR VEuPathDB; TriTrypDB:TcG_12865; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_001939; -.
DR VEuPathDB; TriTrypDB:TCSYLVIO_009681; -.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..700
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004202892"
FT DOMAIN 62..382
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 656..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 700
FT /evidence="ECO:0000313|EMBL:BAA09335.1"
SQ SEQUENCE 700 AA; 77107 MW; B5E6CB448261796B CRC64;
MPRLLLYVLV LFFPLNFCPN VPAHALAPES SRIELFKRKN STVPFEDKGK VTERVVHSFR
LPALVDVDGV MVAIADARYD TSNDNSLIDT VVKYSVDDGE TWETQIGIKN SRVSSVSRVV
DPTVIVKGNK LYVLVGSYNS SRSYWTWQPD GSDWRPMLAV GEVTKSTADG KTTANITWGS
PVSLKEFFPA EMEGMHTKQF LGGAGVATVA SNGNLVSPVQ VTNMKKELFS KIFYSEDDGK
TWNFSEGRSD FGCSEPVVLE WENKFIINTR VDYRRRLVYN SGDMEKPWVE AVGTLSRVWG
PSPKSNQPGS QSSFTAVTIE GMRVMLFTHP LNFKGRWLRD RLHLWLTDNQ RIYNVGQVSI
GDENSAYSSV LYKDDKLYCL HEINTDEVYS LVFARLVGEL RLIKSVVRSW KKWDSHLSSI
CTPADPAASS SERGCGPAVT TVGLAGFLSH SATQNVWEDA YRCVNASTAN AEEVPNGFKF
AGVGGGALWP VSQQGQNQRY HFANYEFTLV ASVTIHEAPR NATPLLGASL DSSGGKKLLG
LSYDEKHQWE PIYGSTPVTP TGSWETGKRY HVALTMANRN GSVYIDGVLL KGSGQTVVPD
ERTPDISHFY IGSYNSSNMP TISHLTANNV LLYNRQLNAE EIRTLFLSQD LIGTEGILDS
SDDDGEDKDS SEYDDGAHSN SSSSFGGDAS SVSAGGRNLP
//
