ID Q27702_MUSDO Unreviewed; 396 AA.
AC Q27702;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=ornithine decarboxylase {ECO:0000256|ARBA:ARBA00034138};
DE EC=4.1.1.17 {ECO:0000256|ARBA:ARBA00034138};
GN Name=ODC {ECO:0000313|EMBL:AAL06466.1,
GN ECO:0000313|RefSeq:NP_001273820.1};
GN Synonyms=101892980 {ECO:0000313|EnsemblMetazoa:MDOA007838-PB};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AAA98981.1};
RN [1] {ECO:0000313|EMBL:AAA98981.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fargo/Orlando {ECO:0000313|EMBL:AAA98981.1};
RA Santoso A., Sparks R.B.;
RT "Housefly Ornithine Decarboxylase: DNA sequence of embryonic RT-PCR
RT clone.";
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAL06466.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fargo/Orlando {ECO:0000313|EMBL:AAL06466.1};
RA Santoso A., Klocke D.J., Sparks R.B.;
RT "Musca domestica ornithine decarboxylase gene.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:MDOA007838-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA007838-PB};
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001273820.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + L-ornithine = CO2 + putrescine; Xref=Rhea:RHEA:22964,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:46911,
CC ChEBI:CHEBI:326268; EC=4.1.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00034037};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via
CC L-ornithine pathway; putrescine from L-ornithine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00034115}.
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|ARBA:ARBA00008872, ECO:0000256|RuleBase:RU003737}.
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DR EMBL; U53667; AAA98981.1; -; mRNA.
DR EMBL; AF411043; AAL06466.1; -; Genomic_DNA.
DR RefSeq; NP_001273820.1; NM_001286891.1.
DR STRING; 7370.Q27702; -.
DR EnsemblMetazoa; MDOA007838-RB; MDOA007838-PB; MDOA007838.
DR GeneID; 101892980; -.
DR KEGG; mde:101892980; -.
DR CTD; 421937; -.
DR VEuPathDB; VectorBase:MDOA007838; -.
DR eggNOG; KOG0622; Eukaryota.
DR OrthoDB; 48358at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0004586; F:ornithine decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00622; PLPDE_III_ODC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR022653; De-COase2_pyr-phos_BS.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR002433; Orn_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR11482; ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE; 1.
DR PANTHER; PTHR11482:SF6; ORNITHINE DECARBOXYLASE 1-RELATED; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01179; ODADCRBXLASE.
DR PRINTS; PR01182; ORNDCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
DR PROSITE; PS00878; ODR_DC_2_1; 1.
PE 2: Evidence at transcript level;
KW Lyase {ECO:0000313|EMBL:AAA98981.1};
KW Polyamine biosynthesis {ECO:0000256|ARBA:ARBA00023115};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 38..271
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 272..370
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 343
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 61
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 396 AA; 44620 MW; B2DDF669825879DE CRC64;
MFKENEINFY ENEIDLKQVI AGQNLQSADE ALFVCDLTRL KEKYDMWTKY MPRVKPYYAV
KCNDDGHIVK TLAELGTNFD CASKGEIKQV LDLGVHPDRI IFAQPCKPIS HLEYAKEMGV
MTSTVDTEFE IHKLHKHFPE SNLVIRFRCE AKEAQCPLGD KFGCDAENEA TSLMLLAKSL
NLKVIGTSFH VGSGCNDLPA YDRAITIAKN LFKFGALLGY EMNLLDIGGG FPGSDNKKFE
KIAEIVNKSL MRHFPDDKVN IIAEPGRFFV ASAYTLICKI HAKGEARLPN GKLLTKMYYL
NDGVYGSFNC ILYDHQHAEV QHFVDEENAE VPKFNSLIWG PTCDALDKIA EDLQLPDLKC
GDFLAFPNMG AYTIPIASPF NGFMLPKILY FHKAKI
//
