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Database: UniProt
Entry: Q27PN4_9HIV1
LinkDB: Q27PN4_9HIV1
Original site: Q27PN4_9HIV1 
ID   Q27PN4_9HIV1            Unreviewed;       182 AA.
AC   Q27PN4;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   04-APR-2006, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ABD50523.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ABD50523.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ABD50523.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ABD50523.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=099v00Rc06 {ECO:0000313|EMBL:ABD50523.1};
RX   PubMed=16775332; DOI=10.1128/JVI.00591-06;
RA   Bailey J.R., Sedaghat A.R., Kieffer T., Brennan T., Lee P.K.,
RA   Wind-Rotolo M., Haggerty C.M., Kamireddi A.R., Liu Y., Lee J., Persaud D.,
RA   Gallant J.E., Cofrancesco J.Jr., Quinn T.C., Wilke C.O., Ray S.C.,
RA   Siliciano J.D., Nettles R.E., Siliciano R.F.;
RT   "Residual human immunodeficiency virus type 1 viremia in some patients on
RT   antiretroviral therapy is dominated by a small number of invariant clones
RT   rarely found in circulating CD4+ T cells.";
RL   J. Virol. 80:6441-6457(2006).
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DR   EMBL; DQ391352; ABD50523.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:ABD50523.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW   Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT   DOMAIN          7..182
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABD50523.1"
FT   NON_TER         182
FT                   /evidence="ECO:0000313|EMBL:ABD50523.1"
SQ   SEQUENCE   182 AA;  21235 MW;  04B48F905A1CD112 CRC64;
     CTEMEKEGKI SKIGPENPYN TPVFAIKKKD STKWRKLVDF RELNKRTQDF WEVQLGIPHP
     AGLKKKKSIT VLDVGDAYFS VPLDKDFRKY TAFTIPSTNN ETPGIRYQYN VLPQGWKGSP
     AIFQCSMTKI LEPFRKQNPD IVIYQYMDDL YVGSDLEIGQ HREKIEELRQ HLMKWGFTTP
     DK
//
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