ID Q27PP8_CRIGR Unreviewed; 115 AA.
AC Q27PP8;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640};
DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003640};
GN Name=NADH3 {ECO:0000313|EMBL:ABD49733.1};
GN Synonyms=ND3 {ECO:0000313|EMBL:ACC86254.1,
GN ECO:0000313|Ensembl:ENSCGRP00001000008.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OG Mitochondrion {ECO:0000313|EMBL:ABD49733.1,
OG ECO:0000313|Ensembl:ENSCGRP00001000008.1}.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:ABD49733.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|EMBL:ABD49733.1, ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=17654009; DOI=10.1080/10425170601101287;
RA Partridge M.A., Davidson M.M., Hei T.K.;
RT "The complete nucleotide sequence of Chinese hamster (Cricetulus griseus)
RT mitochondrial DNA.";
RL DNA Seq. 18:341-346(2007).
RN [2] {ECO:0000313|EMBL:ACC86254.1}
RP NUCLEOTIDE SEQUENCE.
RA Song G.H., Lin Q., Cui P., Liu T.F., Yue W.B.;
RT "Analysis of two hamster mitochondrial genomes.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AOR52800.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:AOR52800.1};
RA Clarke C., Kelly P., Barron N.;
RT "Ultra-deep next generation mitochondrial genome sequencing reveals
RT widespread heteroplasmy in Chinese hamster ovary cells.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSCGRP00001000008.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000766,
CC ECO:0000256|RuleBase:RU003640};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM186.
CC Interacts with TMEM242. {ECO:0000256|ARBA:ARBA00029484}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003640}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family.
CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}.
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DR EMBL; DQ390542; ABD49733.1; -; Genomic_DNA.
DR EMBL; EU660217; ACC86254.1; -; Genomic_DNA.
DR EMBL; KX576660; AOR52800.1; -; Genomic_DNA.
DR RefSeq; YP_537126.1; NC_007936.1.
DR SMR; Q27PP8; -.
DR STRING; 10029.Q27PP8; -.
DR Ensembl; ENSCGRT00001000025.1; ENSCGRP00001000008.1; ENSCGRG00001000025.1.
DR GeneID; 3979190; -.
DR KEGG; cge:3979190; -.
DR CTD; 4537; -.
DR GeneTree; ENSGT00390000011605; -.
DR OMA; RFPVKYY; -.
DR Proteomes; UP000001075; Mitochondrion.
DR Proteomes; UP000694386; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU003640};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640};
KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:ABD49733.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Respiratory chain {ECO:0000256|RuleBase:RU003640};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003640};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003640};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003640};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640};
KW Ubiquinone {ECO:0000256|RuleBase:RU003640}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 55..78
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003640"
SQ SEQUENCE 115 AA; 13091 MW; C28102BE3FAAF112 CRC64;
MNLIMAISTN IILSLVLISV AFWLPQLNTY TEKAGPYECG FDPMSSARLP FSMKFFLVAI
TFLLFDLEIA LLLPLPWAMQ SMTINMMLTI SFLFLSILGL GLAYEWKQKG LEWTE
//
