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Database: UniProt
Entry: Q28115
LinkDB: Q28115
Original site: Q28115 
ID   GFAP_BOVIN              Reviewed;         428 AA.
AC   Q28115; Q0P5L4; Q866S9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   29-OCT-2014, entry version 103.
DE   RecName: Full=Glial fibrillary acidic protein;
DE            Short=GFAP;
GN   Name=GFAP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Subcommissural organ;
RX   PubMed=10571109; DOI=10.1007/s004419900077;
RA   Bouchard P., Ravet V., Meiniel R., Creveaux I., Meiniel A., Vellet A.,
RA   Vigues B.;
RT   "Use of a heterologous monoclonal antibody for cloning and detection
RT   of glial fibrillary acidic protein in the bovine ventricular
RT   ependyma.";
RL   Cell Tissue Res. 298:207-216(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-416.
RA   Guertler M., Alter T., Froeb A., Lange B., Johne R., Luecker E.,
RA   Fehlhaber K.;
RT   "Nucleotide sequence of the bovine glial fibrillary acidic protein
RT   (GFAP) gene.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 197-227.
RX   PubMed=8010535;
RA   Kirkpatrick B.W., Hart G.L.;
RT   "Conformation polymorphisms and targeted marker development.";
RL   Anim. Genet. 25:77-82(1994).
CC   -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-
CC       specific marker that, during the development of the central
CC       nervous system, distinguishes astrocytes from other glial cells.
CC   -!- SUBUNIT: Interacts with SYNM. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q96RG2:PASK (xeno); NbExp=2; IntAct=EBI-907866, EBI-1042651;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Associated
CC       with intermediate filaments. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by PKN1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000305}.
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DR   EMBL; Y08255; CAA69422.1; -; mRNA.
DR   EMBL; BC119892; AAI19893.1; -; mRNA.
DR   EMBL; AY174179; AAO18221.1; ALT_TERM; Genomic_DNA.
DR   EMBL; L19867; AAA51413.1; -; Genomic_DNA.
DR   PIR; PC2280; PC2280.
DR   RefSeq; NP_776490.2; NM_174065.2.
DR   UniGene; Bt.21127; -.
DR   ProteinModelPortal; Q28115; -.
DR   SMR; Q28115; 63-100, 290-368.
DR   IntAct; Q28115; 2.
DR   PaxDb; Q28115; -.
DR   PRIDE; Q28115; -.
DR   Ensembl; ENSBTAT00000017997; ENSBTAP00000017997; ENSBTAG00000013534.
DR   GeneID; 281189; -.
DR   KEGG; bta:281189; -.
DR   CTD; 2670; -.
DR   eggNOG; NOG259463; -.
DR   GeneTree; ENSGT00760000118905; -.
DR   HOGENOM; HOG000230977; -.
DR   HOVERGEN; HBG013015; -.
DR   InParanoid; Q28115; -.
DR   KO; K05640; -.
DR   OMA; ASSNMQE; -.
DR   OrthoDB; EOG7FV3Q8; -.
DR   TreeFam; TF330122; -.
DR   Reactome; REACT_220588; Nuclear signaling by ERBB4.
DR   NextBio; 20805246; -.
DR   GO; GO:0097449; C:astrocyte projection; IEA:Ensembl.
DR   GO; GO:0044297; C:cell body; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005198; F:structural molecule activity; IEA:Ensembl.
DR   GO; GO:0014002; P:astrocyte development; IEA:Ensembl.
DR   GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR   GO; GO:0031102; P:neuron projection regeneration; IEA:Ensembl.
DR   GO; GO:0010625; P:positive regulation of Schwann cell proliferation; IEA:Ensembl.
DR   GO; GO:0051580; P:regulation of neurotransmitter uptake; IEA:Ensembl.
DR   InterPro; IPR027701; GFAP.
DR   InterPro; IPR001664; IF.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR018039; Intermediate_filament_CS.
DR   PANTHER; PTHR23239; PTHR23239; 1.
DR   PANTHER; PTHR23239:SF41; PTHR23239:SF41; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PROSITE; PS00226; IF; 1.
PE   1: Evidence at protein level;
KW   Citrullination; Coiled coil; Complete proteome; Cytoplasm;
KW   Intermediate filament; Phosphoprotein; Reference proteome.
FT   CHAIN         1    428       Glial fibrillary acidic protein.
FT                                /FTId=PRO_0000063804.
FT   REGION        1     68       Head.
FT   REGION       69    373       Rod.
FT   REGION       69    100       Coil 1A.
FT   REGION      101    111       Linker 1.
FT   REGION      112    210       Coil 1B.
FT   REGION      211    226       Linker 12.
FT   REGION      227    248       Coil 2A.
FT   REGION      249    252       Linker 2.
FT   REGION      253    373       Coil 2B.
FT   REGION      374    428       Tail.
FT   MOD_RES       7      7       Phosphothreonine; by AURKB and ROCK1.
FT                                {ECO:0000250}.
FT   MOD_RES      13     13       Phosphoserine; by AURKB and ROCK1.
FT                                {ECO:0000250}.
FT   MOD_RES      26     26       Citrulline. {ECO:0000250}.
FT   MOD_RES      32     32       Citrulline. {ECO:0000250}.
FT   MOD_RES      34     34       Phosphoserine; by AURKB and ROCK1.
FT                                {ECO:0000250}.
FT   MOD_RES     106    106       Phosphothreonine. {ECO:0000250}.
FT   MOD_RES     266    266       Citrulline. {ECO:0000250}.
FT   MOD_RES     379    379       Phosphothreonine. {ECO:0000250}.
FT   MOD_RES     402    402       Citrulline. {ECO:0000250}.
FT   MOD_RES     412    412       Citrulline. {ECO:0000250}.
FT   CONFLICT    265    265       A -> R (in Ref. 1; CAA69422 and 3;
FT                                AAO18221). {ECO:0000305}.
FT   CONFLICT    271    271       L -> V (in Ref. 1; CAA69422 and 3;
FT                                AAO18221). {ECO:0000305}.
FT   CONFLICT    311    312       ER -> DA (in Ref. 1; CAA69422 and 3;
FT                                AAO18221). {ECO:0000305}.
FT   CONFLICT    372    372       R -> Q (in Ref. 3; AAO18221).
FT                                {ECO:0000305}.
FT   CONFLICT    421    421       K -> P (in Ref. 1; CAA69422).
FT                                {ECO:0000305}.
SQ   SEQUENCE   428 AA;  49512 MW;  8DCCDF3E848BAD05 CRC64;
     MERRRVTSAT RRSYVSSSEM VVGGRRLGPG TRLSLARMPP PLPARVDFSL AGALNSGFKE
     TRASERAEMM ELNDRFASYI EKVRFLEQQN KALAAELNQL RAKEPTKLAD VYQAELRELR
     LRLDQLTANS ARLEVERDNL AQDLGTLRQK LQDETNQRLE AENNLAAYRQ EADEATLARL
     DLERKIESLE EEIRFLRKIH EEEVRELQEQ LAQQQVHVEM DVAKPDLTAA LREIRTQYEA
     VASSNMHEAE EWYRSKFADL NDAAARNAEL LRQAKHEAND YRRQLQALTC DLESLRGTNE
     SLERQMREQE ERHAREAASY QEALARLEEE GQSLKDEMAR HLQEYQDLLN VKLALDIEIA
     TYRKLLEGEE NRITIPVQTF SNLQIRETSL DTKSVSEGHL KRNIVVKTVE MRDGEVIKES
     KQEHKDVM
//
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