ID Q28C36_XENTR Unreviewed; 609 AA.
AC Q28C36;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=TRAF-type zinc finger domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040410};
GN ORFNames=TEgg001d16.1-001 {ECO:0000313|EMBL:CAJ81467.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ81467.1};
RN [1] {ECO:0000313|EMBL:CAJ81467.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative feedback regulator that controls excessive innate
CC immune responses. Regulates both Toll-like receptor 4 (TLR4) and
CC DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway
CC by direct interaction with TRAF6 and attenuation of NF-kappa-B
CC activation. May negatively regulate the RLH pathway downstream from
CC MAVS and upstream of NF-kappa-B and IRF3.
CC {ECO:0000256|ARBA:ARBA00037636}.
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DR EMBL; CR942471; CAJ81467.1; -; mRNA.
DR RefSeq; NP_001231772.1; NM_001244843.1.
DR AlphaFoldDB; Q28C36; -.
DR DNASU; 448446; -.
DR GeneID; 448446; -.
DR CTD; 10906; -.
DR OrthoDB; 164168at2759; -.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049439; TRAFD1-XIAF1_Znf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16295:SF19; TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16295; TRAF-TYPE ZINC FINGER PROTEIN-RELATED; 1.
DR Pfam; PF21366; TRAFD1-XIAF1_ZnF; 1.
PE 2: Evidence at transcript level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 94..135
FT /note="TRAFD1/XAF1 zinc finger"
FT /evidence="ECO:0000259|Pfam:PF21366"
FT REGION 588..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 68751 MW; 5397EE8DCAB6F64B CRC64;
MASEAEQETK LCGNCKRDIP LSNFTIHEIH CKRNLSVCDV CKEPVPTADM EEHLATEHMP
VTCKCKMTME KAFLEEHKLS ACPLRLVKCQ FCELEVAFNA LADHEDYCGA RTERCEKCGR
SVMIKDLNDH PDVCGKESVP KKPLLNSGAW FDAIEKDNLH AILPSRFYRN PMFTPSLQNL
HRGAGQDKAV KQTNLTRNIP ARGQEQVSSR RDVLSSSINQ GPSGFSSIRS QRLQNEIGSS
VDPDTDLSAN VNSWRAFDSK DKVAKYRDWQ MESNLFSGDK CVEADSPSAQ TDNQILLPCE
FCEKLFPEED LILHQSGCNP RVFASFCDRR PSPTHFVDFH RDQYVRPVSP PPSVHIPNSI
LIPCEFCGVQ LEEEDLVLHE SGCNPGAFSS FLDQNSPSTR LLDLEQKLLS NRTEQTHDRN
IRPVSPPPPV HKSSNILIPC EFCGVQMEGD VLFHHQDQCD MCPNFEDVPV LQNTRECNDL
QDRLMASQSD DLFHQGRTTA SYTKTTGTGR PTHPGPMTLP ERVPFEPPFI PMVPRTSFAT
HQFNVDERKR NIEENSLHRN RYDSMYSTRL HGGLNPRNVS QLTGIASNNC TSRNKAKEKK
LPGDVDKEE
//