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Database: UniProt
Entry: Q28C36_XENTR
LinkDB: Q28C36_XENTR
Original site: Q28C36_XENTR 
ID   Q28C36_XENTR            Unreviewed;       609 AA.
AC   Q28C36;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   04-APR-2006, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=TRAF-type zinc finger domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040410};
GN   ORFNames=TEgg001d16.1-001 {ECO:0000313|EMBL:CAJ81467.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ81467.1};
RN   [1] {ECO:0000313|EMBL:CAJ81467.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA   Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA   McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA   Zorn A.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative feedback regulator that controls excessive innate
CC       immune responses. Regulates both Toll-like receptor 4 (TLR4) and
CC       DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway
CC       by direct interaction with TRAF6 and attenuation of NF-kappa-B
CC       activation. May negatively regulate the RLH pathway downstream from
CC       MAVS and upstream of NF-kappa-B and IRF3.
CC       {ECO:0000256|ARBA:ARBA00037636}.
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DR   EMBL; CR942471; CAJ81467.1; -; mRNA.
DR   RefSeq; NP_001231772.1; NM_001244843.1.
DR   AlphaFoldDB; Q28C36; -.
DR   DNASU; 448446; -.
DR   GeneID; 448446; -.
DR   CTD; 10906; -.
DR   OrthoDB; 164168at2759; -.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR049439; TRAFD1-XIAF1_Znf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR16295:SF19; TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR16295; TRAF-TYPE ZINC FINGER PROTEIN-RELATED; 1.
DR   Pfam; PF21366; TRAFD1-XIAF1_ZnF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          94..135
FT                   /note="TRAFD1/XAF1 zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF21366"
FT   REGION          588..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..609
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  68751 MW;  5397EE8DCAB6F64B CRC64;
     MASEAEQETK LCGNCKRDIP LSNFTIHEIH CKRNLSVCDV CKEPVPTADM EEHLATEHMP
     VTCKCKMTME KAFLEEHKLS ACPLRLVKCQ FCELEVAFNA LADHEDYCGA RTERCEKCGR
     SVMIKDLNDH PDVCGKESVP KKPLLNSGAW FDAIEKDNLH AILPSRFYRN PMFTPSLQNL
     HRGAGQDKAV KQTNLTRNIP ARGQEQVSSR RDVLSSSINQ GPSGFSSIRS QRLQNEIGSS
     VDPDTDLSAN VNSWRAFDSK DKVAKYRDWQ MESNLFSGDK CVEADSPSAQ TDNQILLPCE
     FCEKLFPEED LILHQSGCNP RVFASFCDRR PSPTHFVDFH RDQYVRPVSP PPSVHIPNSI
     LIPCEFCGVQ LEEEDLVLHE SGCNPGAFSS FLDQNSPSTR LLDLEQKLLS NRTEQTHDRN
     IRPVSPPPPV HKSSNILIPC EFCGVQMEGD VLFHHQDQCD MCPNFEDVPV LQNTRECNDL
     QDRLMASQSD DLFHQGRTTA SYTKTTGTGR PTHPGPMTLP ERVPFEPPFI PMVPRTSFAT
     HQFNVDERKR NIEENSLHRN RYDSMYSTRL HGGLNPRNVS QLTGIASNNC TSRNKAKEKK
     LPGDVDKEE
//
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