ID Q28DA9_XENTR Unreviewed; 833 AA.
AC Q28DA9;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE Flags: Fragment;
GN ORFNames=TEgg124o06.1-001 {ECO:0000313|EMBL:CAJ83736.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ83736.1};
RN [1] {ECO:0000313|EMBL:CAJ83736.1}
RP NUCLEOTIDE SEQUENCE.
RA Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA Zorn A.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR EMBL; CR855605; CAJ83736.1; -; mRNA.
DR AlphaFoldDB; Q28DA9; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd16574; RING-HC_Topors; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR46077; E3 UBIQUITIN-PROTEIN LIGASE TOPORS; 1.
DR PANTHER; PTHR46077:SF1; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 59..98
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..523
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..601
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..681
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..775
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 833
FT /evidence="ECO:0000313|EMBL:CAJ83736.1"
SQ SEQUENCE 833 AA; 95618 MW; 1A8C0EB7114EEC2C CRC64;
MREKRTKRRR PGARQEANDT MMASSSNNYS LDGSFSPQAG TSKLQNHGTS TDASPDSKCP
ICLDRFDNVS HLDRCLHRFC FRCIQEWAKN KAECPLCKQP FYSIFHSVKA EDDFKEYVLR
PTMNGSFASP DGHRFRYRTT MSRDNHVAIR TLRSSSTQRT FSPPDNGILF EGFSNQNLHQ
RGEEIHQMIR RLASRRQASA EGRSMRQIQE QELINFRRAL YRSGIRVRNI QDGGRYRDIS
AEFFRRNPAC LHRLVPWLKR ELTVLFGSHG SLVNIVQHII MSNVTRYDME SQAFVEDLRP
FLLHRTDHFI HEFVNFARCP YNIEAYDQHA NYDCPAPSYE EGSRSESSVI TISPDEADTR
DPIIPSAGPG VGQTAWDDET PGPSYSTLEQ ASVAVSTTLD ISESSDDEPP SIRQTSQEVS
NSEPTENLQD QSFPTDDCVI VGYVKPLAER TPELVELSSD SESSLSEVKT EDAKKPTIKP
FFLSDSSELS RSSSSLYTPA KEKRSRKTKG KTTSSKHSHS RKKEKGKCPL DLTSRKDKGD
LNSNYALSRW RDRSRSSDCY SRSSRNKSHN SRRRHCSKNN LKPRSPEKSR HKSRKGRKKS
SSRDRSLSWR SRTVSLTSES SRERCESSSR SRNRSRGRSR SHDSDNDFSS NNYRSSYQWE
YTYYSRNRDR DGYEQSYRRR TCGRGRYSRP SASPEYKIQS YSEKKDTRKE RGYIASKQYR
RERYRSRSRS SSQMNTSGTE HTRSDKPSGK RKYKTHHLEK QEREGNNREV PSAKEKEGGL
QAGKTSLGNH TGSLKNDLMG SSSEPKQKLR KKARSPSVEI VYEGKAVEGA KHH
//
