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Database: UniProt
Entry: Q28DM4_XENTR
LinkDB: Q28DM4_XENTR
Original site: Q28DM4_XENTR 
ID   Q28DM4_XENTR            Unreviewed;       823 AA.
AC   Q28DM4;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   04-APR-2006, sequence version 1.
DT   22-NOV-2017, entry version 68.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=tcirg1 {ECO:0000313|Ensembl:ENSXETP00000034397,
GN   ECO:0000313|Xenbase:XB-GENE-5721917};
GN   Synonyms=atp6v1b2 {ECO:0000313|EMBL:CAJ82737.1};
GN   ORFNames=TNeu034b02.1-001 {ECO:0000313|EMBL:CAJ82737.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:CAJ82737.1};
RN   [1] {ECO:0000313|EMBL:CAJ82737.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA   Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA   McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G.,
RA   Voigt J., Zorn A.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000034397}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000034397};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3] {ECO:0000313|Ensembl:ENSXETP00000034397}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AAMC01116458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01116459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01116460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01116461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01116462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01116463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR855432; CAJ82737.1; -; mRNA.
DR   RefSeq; NP_001016849.1; NM_001016849.2.
DR   UniGene; Str.10232; -.
DR   STRING; 8364.ENSXETP00000034397; -.
DR   Ensembl; ENSXETT00000034397; ENSXETP00000034397; ENSXETG00000015766.
DR   GeneID; 549603; -.
DR   CTD; 10312; -.
DR   Xenbase; XB-GENE-5721917; tcirg1.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   HOGENOM; HOG000037059; -.
DR   HOVERGEN; HBG014606; -.
DR   OMA; MRISLSW; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-XTR-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Reactome; R-XTR-77387; Insulin receptor recycling.
DR   Reactome; R-XTR-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-XTR-983712; Ion channel transport.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000015766; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    426       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    465       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    543    563       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    570    597       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    639    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    761    785       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   823 AA;  93968 MW;  BF84708576274561 CRC64;
     MGSLFRGEEM CLAQLFLQSG SEYQCVSALG ELGLVEFRDL NQNVNSFQRR YVSEIRRCDE
     METTFSYLER ELRKAGVQVP ESEMSPPAPL PRDAIRMQEE SEQLAKELRE VSQNRQTLQE
     RLRELLEYAN ILRESQRFTG PLLESEAQWK DRSEDDPLLD PAVVNKQDLR VSFMAGVIHP
     WRMNSFERLL WRACRGYLIV NFVEMSEPME DLVTGESVTQ IIFLISYWGE KIGEKIKKIA
     NCFHCHIYPY ADDETSRLET LRNLLVQIQD MQKVLLQTEG YLSQVLSRAA SALHHWRVSV
     RKMKHIYLIL NLCSVRERCL IGEVWCPVVD LPLLQSALTR ASESSGGGGE SFCHRIPCAF
     SPPTLIRTNK FTSGFQGIVD AYGVATYQEV NPAIFSIITF PFLFAVMFGD VGHGAIMFLF
     ALWLVLGEND PKLRRSEDEI FSMCFGGRYL ILLMGALSVY TGFVYNECFS RPAVIFNSGW
     SVASMARANN WTSDSINKLP PIPLNPNITG VFTAPYPFGI DPIWSLAVNR LTFLNSFKMK
     MSVILGVCHM AFGVCLSVFN FVHFRQIYRI FLITLPELLF LLCLFGYLVF MVVYKWIVLT
     AEDAEWAPSI LIHFIDMFLF TQNPGNRDLY QGQQVVQTVL VIVAILCIPV LLLGDPICLL
     IQHRSKKDSS HQNRCSLNNG DREALLEDEI TVPTGHGHGS EKFDTAEVFM HQMIHTIEYC
     LGCISNTASY LRLWALSLAH AQLSEVLWNM VIRIGFSKLS LTWGIVLVPI FAFFAVLTVA
     ILLIMEGLSA FLHALRLHWV EFQNKFYSGE GYKFFPFCFE TMY
//
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