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Database: UniProt
Entry: Q28RA7
LinkDB: Q28RA7
Original site: Q28RA7 
ID   RND_JANSC               Reviewed;         386 AA.
AC   Q28RA7;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   29-OCT-2014, entry version 50.
DE   RecName: Full=Ribonuclease D {ECO:0000255|HAMAP-Rule:MF_01899};
DE            Short=RNase D {ECO:0000255|HAMAP-Rule:MF_01899};
DE            EC=3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899};
GN   Name=rnd {ECO:0000255|HAMAP-Rule:MF_01899};
GN   OrderedLocusNames=Jann_1838;
OS   Jannaschia sp. (strain CCS1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Jannaschia.
OX   NCBI_TaxID=290400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCS1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Chertkov O., Saunders E.,
RA   Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Moran M.A.,
RA   Belas R., Ye W., Buchan A., Gonzalez J.M., Schell M.A., Richardson P.;
RT   "Complete sequence of chromosome of Jannaschia sp. CCS1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exonuclease involved in the 3' processing of various
CC       precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA
CC       molecule and releases 5'-mononucleotides. {ECO:0000255|HAMAP-
CC       Rule:MF_01899}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage that removes extra
CC       residues from the 3'-terminus of tRNA to produce 5'-
CC       mononucleotides. {ECO:0000255|HAMAP-Rule:MF_01899}.
CC   -!- COFACTOR: Divalent cation. {ECO:0000255|HAMAP-Rule:MF_01899}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01899}.
CC   -!- SIMILARITY: Belongs to the RNase D family. {ECO:0000255|HAMAP-
CC       Rule:MF_01899}.
CC   -!- SIMILARITY: Contains 1 3'-5' exonuclease domain.
CC       {ECO:0000255|HAMAP-Rule:MF_01899}.
CC   -!- SIMILARITY: Contains 1 HRDC domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01899}.
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DR   EMBL; CP000264; ABD54755.1; -; Genomic_DNA.
DR   RefSeq; WP_011454960.1; NC_007802.1.
DR   RefSeq; YP_509780.1; NC_007802.1.
DR   ProteinModelPortal; Q28RA7; -.
DR   STRING; 290400.Jann_1838; -.
DR   EnsemblBacteria; ABD54755; ABD54755; Jann_1838.
DR   GeneID; 3934289; -.
DR   KEGG; jan:Jann_1838; -.
DR   PATRIC; 22147408; VBIJanSp43325_1971.
DR   eggNOG; COG0349; -.
DR   HOGENOM; HOG000277561; -.
DR   KO; K03684; -.
DR   OMA; QDLEIIW; -.
DR   OrthoDB; EOG6MM1MT; -.
DR   BioCyc; JSP290400:GI1R-1853-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0033890; F:ribonuclease D activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0042780; P:tRNA 3'-end processing; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_01899; RNase_D; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR006292; RNase_D.
DR   InterPro; IPR012337; RNaseH-like_dom.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF47819; SSF47819; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   TIGRFAMs; TIGR01388; rnd; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Exonuclease; Hydrolase; Nuclease;
KW   Reference proteome; tRNA processing.
FT   CHAIN         1    386       Ribonuclease D.
FT                                /FTId=PRO_0000411065.
FT   DOMAIN        3    174       3'-5' exonuclease. {ECO:0000255|HAMAP-
FT                                Rule:MF_01899}.
FT   DOMAIN      213    294       HRDC. {ECO:0000255|HAMAP-Rule:MF_01899}.
SQ   SEQUENCE   386 AA;  42398 MW;  89E9EF4C81B863BD CRC64;
     MPHTITTTDE LAAYCARAAT QPYVTVDTEF LRERTYFAQL CLVQVAMPGT DDTDAVLIDP
     LAEGLSLEPL YELFRNVNVV KVFHAARQDL EIFFVEGGLV PTPLFDTQVA AMVCGFGDQV
     GYETLVRRIA KANLDKSSRF TDWSRRPLSD AQKVYALADV TYLREIYEYL SAELARTDRT
     HWLEEELAQL TNADAYVVDP ENAWKRLKLR SNSGRVVAIA QQLAAFRETY AQEKNVPRNR
     VLKDDALLEL AGTKPKTVAD LGKSRLLLRD ARKGAIAEGL VAAVARGMSV PNSEIPKVQA
     GRDRSNLNPA LADLLRVLLK AKAENAGVAT KLIASSSDLD DIASGFTDGV WASGWRSEVF
     GADALRLLNG EVALAAKGQK VKIVEV
//
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