ID   Q29L36_DROPS            Unreviewed;       800 AA.
AC   Q29L36; A0A6I8UI75;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 3.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Proton channel OtopLc isoform X1 {ECO:0000313|RefSeq:XP_001355929.3};
GN   Name=LOC4816398 {ECO:0000313|RefSeq:XP_001355929.3};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001355929.3};
RN   [1] {ECO:0000313|RefSeq:XP_001355929.3}
RP   IDENTIFICATION.
RC   STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001355929.3};
RC   TISSUE=Whole body {ECO:0000313|RefSeq:XP_001355929.3};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the otopetrin family.
CC       {ECO:0000256|ARBA:ARBA00006513}.
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DR   RefSeq; XP_001355929.3; XM_001355893.4.
DR   AlphaFoldDB; Q29L36; -.
DR   STRING; 46245.Q29L36; -.
DR   EnsemblMetazoa; FBtr0289152; FBpp0287590; FBgn0077398.
DR   GeneID; 4816398; -.
DR   KEGG; dpo:4816398; -.
DR   eggNOG; KOG4740; Eukaryota.
DR   HOGENOM; CLU_011508_1_1_1; -.
DR   InParanoid; Q29L36; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0077398; Expressed in adult organism.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015252; F:proton channel activity; IEA:InterPro.
DR   InterPro; IPR004878; Otopetrin.
DR   PANTHER; PTHR21522:SF30; GH01206P; 1.
DR   PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR   Pfam; PF03189; Otopetrin; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ   SEQUENCE   800 AA;  89959 MW;  39EB17C0882A9B40 CRC64;
     MSLSNLKSSA MYDEPINLWK TKQRVHYHDD VVAKKKNRQI PTDVCEYISI SAPKKSDSFS
     RLPPNSLPSS VPGTPPHSVG TTSNQVIRYA RTSCDHCGHH SIPVMSPHPI SPLAKSQTNL
     DVVEHSSQRH ALLPMPTIGF HRDDSACTLQ VSRRPSLLLQ EILTQRPPMF GRKDGNGFLS
     PRAAKGNLQS TASGSTATIN LQSGTASARN GSTAFFDNGA KSYQAKQQKE KNRRTGNDAI
     SSALSATYCK LLVLLGVCLP ITEVISEQIP TYVYQGFYVY LYVGSILFVI FLYISAFRNR
     SLFNALKDFH EKNSNVHLKH KVTHFGSFYL RVGAIAFAIG TMVYSGLEFG QFFELNGHPG
     CRDVFVAITP ICRMVLCIAQ VQFIFLNTTY MDMARHKVTS RFGLMHMVAT NLCEWLYVLV
     EETKHEIFHI SHHDVDPDND PIMHNGTHGL PNWSAMNESL NHHKAHLTVK DPLNHTILAN
     VSSIIANVTA TPSSTPASFT GCSRTTIMGA LVQQLSPFLF PCTIEYSLIC AVILYEMWKT
     VKSIPDIDKT RKNSVKPVAQ KPAHHFSVDC SQSHKGLFFG ILIIVMTIIS MIMYFVLYTQ
     PGYELVATQE VTLWETFMYF MCAAAVITGM FLMRDLRYIK DTSDEHHSMD LDNLLLIVAQ
     TGVYLYGLFS ILGSYFAKWD TVPDRVEGII AEVFGVVQTS LQTMFILHAS HRRCKGAKQV
     RRKPGREIIT FLLVANIAIW FVNTLIKGRA VFRESHLEFF GVWGWTIITH ISMPLAIFYR
     FHSTICLFEV WKITYKAKAH
//