ID Q29R87_DANRE Unreviewed; 289 AA.
AC Q29R87; A8E5B5; F6P1Z8;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE RecName: Full=ETS homologous factor {ECO:0000256|ARBA:ARBA00018937};
DE AltName: Full=ETS domain-containing transcription factor {ECO:0000256|ARBA:ARBA00031474};
GN Name=ehf {ECO:0000313|Ensembl:ENSDARP00000068397,
GN ECO:0000313|ZFIN:ZDB-GENE-060312-7};
GN ORFNames=zgc:136967 {ECO:0000313|EMBL:AAI53534.1,
GN ECO:0000313|RefSeq:NP_001034911.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI53534.1};
RN [1] {ECO:0000313|EMBL:AAI53534.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAI53534.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001034911.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18832752;
RA Liu F., Patient R.;
RT "Genome-wide analysis of the zebrafish ETS family identifies three genes
RT required for hemangioblast differentiation or angiogenesis.";
RL Circ. Res. 103:1147-1154(2008).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000068397}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000068397};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000068397, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000068397};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001034911.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|RefSeq:NP_001034911.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29042681;
RA Wang J., Leng X., Wang G., Wan X., Cao H.;
RT "The construction of intrahepatic cholangiocarcinoma model in zebrafish.";
RL Sci. Rep. 7:13419-13419(2017).
RN [7] {ECO:0000313|RefSeq:NP_001034911.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; BX120011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114327; AAI14328.1; -; mRNA.
DR EMBL; BC153533; AAI53534.1; -; mRNA.
DR RefSeq; NP_001034911.1; NM_001039822.1.
DR STRING; 7955.ENSDARP00000068397; -.
DR PaxDb; 7955-ENSDARP00000068397; -.
DR Ensembl; ENSDART00000073907; ENSDARP00000068397; ENSDARG00000052115.
DR Ensembl; ENSDART00000073907.5; ENSDARP00000068397.4; ENSDARG00000052115.7.
DR GeneID; 568223; -.
DR KEGG; dre:568223; -.
DR AGR; ZFIN:ZDB-GENE-060312-7; -.
DR CTD; 26298; -.
DR ZFIN; ZDB-GENE-060312-7; ehf.
DR eggNOG; KOG3804; Eukaryota.
DR HOGENOM; CLU_048172_0_0_1; -.
DR OMA; CGSEMYP; -.
DR OrthoDB; 3686750at2759; -.
DR TreeFam; TF318679; -.
DR Proteomes; UP000000437; Alternate scaffold 25.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000052115; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd08539; SAM_PNT-ESE-3-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR033071; EHF_SAM_Pointed_dom.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF171; ETS HOMOLOGOUS FACTOR; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 34..120
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 196..278
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 171..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 289 AA; 33561 MW; 150E74AEC63BAC8E CRC64;
MVLQASGVMS IPATVSVDNQ LPASWTTHYN CTDVSMMTSN FTSRLWTQDP HPQNWTKFQV
WEWLQQTLDM HQIDATSIPF QNFDLDGRQL CNMSFQDFTR AAGSVGSILF QSLTDLKWNG
QYGQTDMFTP ADIKTEIDAD FPCSILPFKE ESSFYSNPEL FDIKSSFQPS SILPSPAPSS
PDPKRSQVKR HNPRGTHLWE FIRDILLNPE RNPGLIKWED RSEGVFRFLK SEAVAQLWGK
KKNNSSMTYE KLSRAMRYYY KREILERVDG RRLVYKFGRN ARGWRESEK
//
