ID   Q29RH8_BOVIN            Unreviewed;       439 AA.
AC   Q29RH8;
DT   04-APR-2006, integrated into UniProtKB/TrEMBL.
DT   04-APR-2006, sequence version 1.
DT   24-JAN-2024, entry version 103.
DE   RecName: Full=Protein-serine/threonine kinase {ECO:0000256|RuleBase:RU366032};
DE            EC=2.7.11.- {ECO:0000256|RuleBase:RU366032};
DE   Flags: Fragment;
GN   Name=PDK2 {ECO:0000313|EMBL:AAI14167.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI14167.1};
RN   [1] {ECO:0000313|EMBL:AAI14167.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI14167.1};
RC   TISSUE=Heart ventrical {ECO:0000313|EMBL:AAI14167.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|RuleBase:RU366032}.
CC   -!- SIMILARITY: Belongs to the PDK/BCKDK protein kinase family.
CC       {ECO:0000256|ARBA:ARBA00006155, ECO:0000256|RuleBase:RU366032}.
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DR   EMBL; BC114166; AAI14167.1; -; mRNA.
DR   RefSeq; NP_001152953.1; NM_001159481.1.
DR   AlphaFoldDB; Q29RH8; -.
DR   GeneID; 524075; -.
DR   CTD; 5164; -.
DR   HOGENOM; CLU_023861_1_1_1; -.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd16929; HATPase_PDK-like; 1.
DR   Gene3D; 1.20.140.20; Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR036784; AK/P_DHK_N_sf.
DR   InterPro; IPR018955; BCDHK/PDK_N.
DR   InterPro; IPR039028; BCKD/PDK.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   PANTHER; PTHR11947:SF15; [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11947; PYRUVATE DEHYDROGENASE KINASE; 1.
DR   Pfam; PF10436; BCDHK_Adom3; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF69012; alpha-ketoacid dehydrogenase kinase, N-terminal domain; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU366032};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU366032};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU366032};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU366032};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU366032};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          274..396
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAI14167.1"
SQ   SEQUENCE   439 AA;  49433 MW;  2E5746603C74CE84 CRC64;
     GRRGTGPDWA EQSASAARAG SRTRVLEVVA IAMRWVRALL KNASLAGAPK YIEHFSKFSP
     SPLSMKQFLD FGSSNACEKT SFTFLRQELP VRLANIMKEI NLLPDRVLST PSVQLVQSWY
     VQSLLDIMEF LDKDPEDHRT LSQFTDALVT IRNRHNDVVP TMAQGVLEYK DTYGDDPVSN
     QNIQYFLDRF YLSRISIRML INQHTLLFDG RTNPAHPKHI GSIDPNCNVS EVVKDAYDMA
     KLLCDKYYMA SPDLEIQEIN ASNSKQPIHM VYVPSHLYHM LFELFKNAMR ATVESHESSV
     TLPPVKVMVA LGEEDLSIKM SDRGGGVPLR KIDRLFSYMY STAPTPQPGT GGTPLAGFGY
     GLPISRLYAK YFQGDLQLFS MEGFGTDAVI YLKALSTDSV ERLPVYNKSA WRHYQTIQEA
     GDWCVPSTEP KNTSTYRVS
//