ID Q2AB61_XENTR Unreviewed; 296 AA.
AC Q2AB61; F6WDC5; F7D4P0;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=t2r22 {ECO:0000313|RefSeq:NP_001165481.1,
GN ECO:0000313|Xenbase:XB-GENE-29099551};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:BAE80406.1};
RN [1] {ECO:0000313|EMBL:BAE80406.1, ECO:0000313|RefSeq:NP_001165481.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16484289; DOI=10.1093/molbev/msj106;
RG SMBE Tri-National Young Investigators;
RA Go Y.;
RT "Lineage-specific expansions and contractions of the bitter taste receptor
RT gene repertoire in vertebrates.";
RL Mol. Biol. Evol. 23:964-972(2006).
RN [2] {ECO:0000313|RefSeq:NP_001165481.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AB249790; BAE80406.1; -; Genomic_DNA.
DR RefSeq; NP_001165481.1; NM_001172010.1.
DR STRING; 8364.ENSXETP00000033630; -.
DR PaxDb; 8364-ENSXETP00000018685; -.
DR GeneID; 100335073; -.
DR KEGG; xtr:100335073; -.
DR CTD; 100335073; -.
DR Xenbase; XB-GENE-29099551; t2r22.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR HOGENOM; CLU_072337_3_1_1; -.
DR OMA; TAWLSIC; -.
DR OrthoDB; 4631596at2759; -.
DR PhylomeDB; Q2AB61; -.
DR TreeFam; TF335891; -.
DR Proteomes; UP000008143; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF144; TASTE RECEPTOR TYPE 2; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU004424, ECO:0000313|EMBL:BAE80406.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 296 AA; 33826 MW; 7125D7D9E04B5CC6 CRC64;
MLFFINVIKI TYLIVTWLCG SILNSSIVAV YLREWKNGMS LGECDRTILT MGCNNLFLQC
FLTMNEVITI FELYGLFLKE FTLVGCILYF FLCYVSMWLT AWLSICYYVK LVNFSHRLLI
RFKRTIPSAS APFLFGSVVG SCLINVPFIW TMDTEFLQNT TVSAENFLFK MDLRFMSFNV
VIGSCVPVLV TSVCMGFSVM SLLRHVQRMK NNTSQSWNPQ SKSHVRACRT MSLLMIMNLI
FFLAVITVAM GLTKFNAIIA RRIIYWLVVM ASPSAEAIIL ILGNTKLKMA LPKICF
//
