ID Q2AB75_XENTR Unreviewed; 317 AA.
AC Q2AB75;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=t2r6 {ECO:0000313|RefSeq:NP_001165469.1,
GN ECO:0000313|Xenbase:XB-GENE-29099651};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:BAE80392.1};
RN [1] {ECO:0000313|EMBL:BAE80392.1, ECO:0000313|RefSeq:NP_001165469.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16484289; DOI=10.1093/molbev/msj106;
RG SMBE Tri-National Young Investigators;
RA Go Y.;
RT "Lineage-specific expansions and contractions of the bitter taste receptor
RT gene repertoire in vertebrates.";
RL Mol. Biol. Evol. 23:964-972(2006).
RN [2] {ECO:0000313|RefSeq:NP_001165469.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AB249774; BAE80392.1; -; Genomic_DNA.
DR RefSeq; NP_001165469.1; NM_001171998.1.
DR GeneID; 100335059; -.
DR KEGG; xtr:100335059; -.
DR CTD; 100335059; -.
DR Xenbase; XB-GENE-29099651; t2r6.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR HOGENOM; CLU_072337_3_0_1; -.
DR OMA; CITYVVE; -.
DR OrthoDB; 5306466at2759; -.
DR PhylomeDB; Q2AB75; -.
DR TreeFam; TF335891; -.
DR Proteomes; UP000008143; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF47; TASTE RECEPTOR TYPE 2 MEMBER 1-RELATED; 1.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU004424, ECO:0000313|EMBL:BAE80392.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 317 AA; 36195 MW; 1A2414221236CF54 CRC64;
MSYLIDDVLS TVFSVTAVLL GLAVNGFIPL VNIKDWVTVR KMKPSDRILT VLCSTRFLLQ
FTFFLELTGI SFGLIPLSAY AAYCITYVVE LLLDLFSHWL SMWLCCLYYV KITTSKHPLI
LHLKSRIPGI TKYALLLFGF LSFLTGLVYY VSGDDISCLH GISKNLTANR TFESLQERLM
IAYFFGQAFP FMMEMMSSMY LLSLLVSHVK HTMSNFSSFK APSMDAHWSL IRYILLLYFL
SACNLVGNLL LWQVTSHSIG RSVGYFIIFS YPSFHSITLV LCNPKLKREM VKTFIWTRNV
LCCFRGDGGF RTETVAQ
//
