ID Q2C4D1_9GAMM Unreviewed; 1177 AA.
AC Q2C4D1;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SKA34_16950 {ECO:0000313|EMBL:EAR55877.1};
OS Photobacterium sp. SKA34.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=121723 {ECO:0000313|EMBL:EAR55877.1, ECO:0000313|Proteomes:UP000005284};
RN [1] {ECO:0000313|EMBL:EAR55877.1, ECO:0000313|Proteomes:UP000005284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SKA34 {ECO:0000313|EMBL:EAR55877.1,
RC ECO:0000313|Proteomes:UP000005284};
RA Hagstrom A.J., Ferriera S., Johnson J., Kravitz S., Halpern A.,
RA Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR55877.1}.
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DR EMBL; AAOU01000013; EAR55877.1; -; Genomic_DNA.
DR RefSeq; WP_006647484.1; NZ_CH724146.1.
DR AlphaFoldDB; Q2C4D1; -.
DR REBASE; 24006; Psp34ORF16950P.
DR HOGENOM; CLU_007510_1_0_6; -.
DR OrthoDB; 9782445at2; -.
DR Proteomes; UP000005284; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 291..361
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 472..560
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 1177 AA; 134438 MW; FA869FC8C55EFCB4 CRC64;
MDTSRLKKFA QYARRSLIDQ VESKLKLVLA DESQARRESP SAVAELEKKL KQHGQDDKAR
EQLVEQVAYT WFNRFCALRF MDVNQYNRIM VLSPLPGQFQ PEILTEAKAG HIDEGIVNKA
TQEKTFGLLG GSIASRDGQS EAFRLLIVAV CNDLHRIMPY LFERIEDYTE LLMPDDLLSG
NSILAYTREA MTPEACESVE SIGWLYQFYI SEKKDQVFDG LKKNKKITPE NIPAATQLFT
PHWIVRYLVE NSLGRLWMLN NPDSKVIDQM DYYIKPAEVE TDFLRISSPE DIKVCDPACG
SGHMLTYSYD LLYAIYSSTG EYDDSEIPEL ILTKNLYGIE IDERAAELAA FALTMKALKG
DPLGKSNNRR RFFRNPVKPN ICRLEKVIFS DDELNSYIDF AGKDLFSQEL RLTLKEFEEA
DNLGSLIQPT LKMPADTLAI FEGKDVSGEL FLADTHQSIL TVLQQADYLS PKYNVVVANP
PYMGSKGMNN RLSKWAKDNY PDSRSDLFSM FIERDLKLVV KSGYSAMINM QSWMFLSSFE
KLRLKLLEES TIVSMCHLGT RAFDSIGGEV VSTTAYVLRN GIDISFKGDY IRLVEGRSEK
EKEQSLLEAV ANKTCDYLFQ VSANHFNAIP GSPIAYWVET KIIETFSSAQ PFGRVGKTRR
GLQTGDSDRF IRRWYEVSLD NIGRGLTKEA AEKSGCNWFL FNSGGTFRKW YGNIEDVVNW
GKDGQEIKAS GKAIIPSEDL YFKKAITWPK VSGGRCSFRW FPDGIIPGDA GPCFYDESSS
EDAVLCFSNS KVALSFLQFL SPTLNFEVGV MAKMPLIVPA TDELKLTRNE SIKIHKEDWD
SSEMSCDFTF SPVAAYRHRQ TRLEDSYQQL RTNWNDVTLR MKRIEEDNNR LFINLYGLSD
TLTPDVPLSE ITLSFNPHYR FGTDKTELEL ESLIKKDTLI AFISYAVGCI FGRYSLDKEG
LILANQSDTL ECYLKQVPQP SFMPDKDNVI PLIDFDGDWF EDDITERFNE FLKVTFGEEH
FTENLTFIED AIGKDIKKFF LKDFYTDHVK CYKKRPIYWM FSSPKGSFNA LIYMHRYRTD
TVSVVLNDYL REFRTKLQAR KESYEQIEIS ASASPGEKTK AIKAIQNVNK VLDEINDYEH
ETLYPLAGKP PEIDLDDGVK HNYPLFGKAL KKVTGLS
//
