ID Q2CA35_OCEGH Unreviewed; 315 AA.
AC Q2CA35;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:EAR49530.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:EAR49530.1};
GN ORFNames=OG2516_12829 {ECO:0000313|EMBL:EAR49530.1};
OS Oceanicola granulosus (strain ATCC BAA-861 / DSM 15982 / KCTC 12143 /
OS HTCC2516).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Oceanicola.
OX NCBI_TaxID=314256 {ECO:0000313|EMBL:EAR49530.1, ECO:0000313|Proteomes:UP000003635};
RN [1] {ECO:0000313|EMBL:EAR49530.1, ECO:0000313|Proteomes:UP000003635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-861 / DSM 15982 / KCTC 12143 / HTCC2516
RC {ECO:0000313|Proteomes:UP000003635};
RX PubMed=20418400; DOI=10.1128/JB.00412-10;
RA Thrash J.C., Cho J.C., Vergin K.L., Giovannoni S.J.;
RT "Genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola
RT batsensis HTCC2597(TDelta).";
RL J. Bacteriol. 192:3549-3550(2010).
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR49530.1}.
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DR EMBL; AAOT01000062; EAR49530.1; -; Genomic_DNA.
DR RefSeq; WP_007256082.1; NZ_CH724108.1.
DR AlphaFoldDB; Q2CA35; -.
DR STRING; 314256.OG2516_12829; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_0_0_5; -.
DR OrthoDB; 9803287at2; -.
DR Proteomes; UP000003635; Unassembled WGS sequence.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:EAR49530.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003635}.
FT DOMAIN 7..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..252
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 315 AA; 33959 MW; 359FFA468D6C8820 CRC64;
MKSHPPVACV GTGLVGRSWA IVFARAGHEV RLWDAQAGTA EAARDFAAEM LPELERLGLI
EGAAADALAR ITPVAELEAA LDGVAHVQES TPEEIGLKRE VFGRLDALAG PDTVLASSSS
ALLPSAISEG LAGRHRCMVN HPINPAYLVP AAELVPAPWT EPALVARTAD MLRAAGMRPM
VMNKEIQGFV MNRLQGALLH EAFRLVADGY ASAEDVDIGL REGLALRWSF IGPFETIDLN
APEGVRQYVE RYSGIYTGLS DQPPADWQGP VLDRIEAERR AALPGDELAA RQAWRDRRLM
ALAAHKRRAA DEIGE
//
