ID Q2CK16_OCEGH Unreviewed; 495 AA.
AC Q2CK16;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:EAR52973.1};
GN ORFNames=OG2516_10936 {ECO:0000313|EMBL:EAR52973.1};
OS Oceanicola granulosus (strain ATCC BAA-861 / DSM 15982 / KCTC 12143 /
OS HTCC2516).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Oceanicola.
OX NCBI_TaxID=314256 {ECO:0000313|EMBL:EAR52973.1, ECO:0000313|Proteomes:UP000003635};
RN [1] {ECO:0000313|EMBL:EAR52973.1, ECO:0000313|Proteomes:UP000003635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-861 / DSM 15982 / KCTC 12143 / HTCC2516
RC {ECO:0000313|Proteomes:UP000003635};
RX PubMed=20418400; DOI=10.1128/JB.00412-10;
RA Thrash J.C., Cho J.C., Vergin K.L., Giovannoni S.J.;
RT "Genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola
RT batsensis HTCC2597(TDelta).";
RL J. Bacteriol. 192:3549-3550(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR52973.1}.
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DR EMBL; AAOT01000001; EAR52973.1; -; Genomic_DNA.
DR RefSeq; WP_007255707.1; NZ_CH724107.1.
DR AlphaFoldDB; Q2CK16; -.
DR STRING; 314256.OG2516_10936; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_022247_0_0_5; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000003635; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000003635}.
FT ACT_SITE 76
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 76
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 176
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 324
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 333
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 337
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 495 AA; 54721 MW; FFE5C1C4592EF686 CRC64;
MTGPARHIVI VGGGTAGWLA ALILARRDDL RVTVVESSRI PTIGVGEGTT AVFRQMLQHL
GLDERAFLAA TGATIKYGIR HRDWRRVGHS YDGPIDDTAQ VAGPGLDLYA VASGRPVAEV
HLFGTLMDRR RAPVAEVGGR EVPAGPFHWA YHFDQARAGA WLKRQATGVT VVDDVVAGLE
RDGEGGDITA LRLESGARLE GDLFIDCTGF RRALIGPMGA EWVSYGDVLP VNRAMPFWID
LQEGEEIDPF TLAHAQGAGW MWKIPTTERY GCGYVYSDAH TTPDAAQAEI EAALGRAIEP
RNDIRIDAGR LREAWIGNCV AIGLASSFLE PLEATSIHGT IVQLMWLDSL LAAPDGAARY
NAAVARQVDD FRDFIRLHYV SERRDTAFWR DVAASHPPEV RARLDLWRHR LPERRDFAPV
PLDLPHVQEQ LYTPVLDGLG LLDRASARAA LADHPHRRAR LRKTHEQLTK DHRRAAGRCR
PHRAWLSSLR EEIPA
//
