ID Q2EJC0_DROME Unreviewed; 449 AA.
AC Q2EJC0;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Catsup protein {ECO:0000313|EMBL:ABD37860.1};
GN Name=Catsup {ECO:0000313|FlyBase:FBgn0002022};
GN ORFNames=CG10449 {ECO:0000313|FlyBase:FBgn0002022};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABD37860.1};
RN [1] {ECO:0000313|EMBL:ABD37860.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Raleigh wild {ECO:0000313|EMBL:ABD37860.1};
RX PubMed=16682353; DOI=10.1016/j.cub.2006.03.051;
RA Carbone M.A., Jordan K.W., Lyman R.F., Harbison S.T., Leips J.,
RA Morgan T.J., DeLuca M., Awadalla P., Mackay T.F.;
RT "Phenotypic variation and natural selection at catsup, a pleiotropic
RT quantitative trait gene in Drosophila.";
RL Curr. Biol. 16:912-919(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000256|ARBA:ARBA00038485}.
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DR EMBL; DQ375969; ABD37860.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2EJC0; -.
DR AGR; FB:FBgn0002022; -.
DR FlyBase; FBgn0002022; Catsup.
DR VEuPathDB; VectorBase:FBgn0002022; -.
DR HOGENOM; CLU_015114_0_1_1; -.
DR ChiTaRS; Catsup; fly.
DR ExpressionAtlas; Q2EJC0; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR16950:SF25; ZINC TRANSPORTER SLC39A7; 1.
DR PANTHER; PTHR16950; ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 57..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 48644 MW; B2433C554B75DE4E CRC64;
MAKQVADYQC SKLQLYQKLA LVVILGAVLF SLPALCAGQG NPSFKYSREA NENFDPQKAP
RAEHHHHHDH DHDHGHHHHG HDHDHDHDHG HDHGHHHHGH DHDHDHDHGH HHHGHDERHT
KAKPDLDMST IWLHSIGSTL LISAAPFVLL YIIPLDNSEA MKPRLKVLLA FASGGLLGDA
FLHLIPHATH PHSHGEHGHD HGHDHHHHHD GEEHEHGHSH DMSIGLWVLG GIIAFLSVEK
LVRILKGGHG GHGHSHGAPN PKPVPAKKKS SDKEDSGDGD KPAKPAKIKS KKPEAEPEGE
VEISGYLNLA ADFAHNFTDG LAIGASYLAG NSIGIVTTIT ILLHEVPHEI GDFAILIKSG
CSRRKAMLLQ LVTALGALAG TALALLGAGG GDGSAPWVLP FTAGGFIYIA TVSVLPELLE
ESTKLKQSLK EIFALLTGVA LMIVIAKFE
//
