GenomeNet

Database: UniProt
Entry: Q2ES93_9FLAV
LinkDB: Q2ES93_9FLAV
Original site: Q2ES93_9FLAV 
ID   Q2ES93_9FLAV            Unreviewed;       774 AA.
AC   Q2ES93;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   24-JAN-2024, entry version 86.
DE   RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE   Flags: Fragment;
OS   Dengue virus.
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC   Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus denguei.
OX   NCBI_TaxID=12637 {ECO:0000313|EMBL:ABD15346.1};
RN   [1] {ECO:0000313|EMBL:ABD15346.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PR_15_88 {ECO:0000313|EMBL:ABD15346.1};
RX   PubMed=16528038; DOI=10.1099/vir.0.81309-0;
RA   Bennett S.N., Holmes E.C., Chirivella M., Rodriguez D.M., Beltran M.,
RA   Vorndam V., Gubler D.J., McMillan W.O.;
RT   "Molecular evolution of dengue 2 virus in Puerto Rico: positive selection
RT   in the viral envelope accompanies clade reintroduction.";
RL   J. Gen. Virol. 87:885-893(2006).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004367}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004367}; Lumenal side
CC       {ECO:0000256|ARBA:ARBA00004367}. Host endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004153}. Host endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00023443}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00023443}; Lumenal side
CC       {ECO:0000256|ARBA:ARBA00023443}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004385}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ364552; ABD15346.1; -; Genomic_RNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IEA:UniProtKB-KW.
DR   GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   CDD; cd12149; Flavi_E_C; 1.
DR   CDD; cd17038; Flavi_M; 1.
DR   Gene3D; 1.10.10.930; -; 1.
DR   Gene3D; 1.20.1280.260; -; 1.
DR   Gene3D; 2.60.40.350; -; 1.
DR   Gene3D; 1.10.8.970; Flavivirus envelope glycoprotein M-like; 1.
DR   Gene3D; 2.60.260.50; Flavivirus polyprotein propeptide domain; 1.
DR   Gene3D; 2.60.98.10; Tick-borne Encephalitis virus Glycoprotein, domain 1; 1.
DR   Gene3D; 3.30.67.10; Viral Envelope Glycoprotein, domain 2; 1.
DR   Gene3D; 3.30.387.10; Viral Envelope Glycoprotein, domain 3; 1.
DR   InterPro; IPR000069; Env_glycoprot_M_flavivir.
DR   InterPro; IPR038302; Env_glycoprot_M_sf_flavivir.
DR   InterPro; IPR013755; Flav_gly_cen_dom_subdom1.
DR   InterPro; IPR001122; Flavi_capsidC.
DR   InterPro; IPR037172; Flavi_capsidC_sf.
DR   InterPro; IPR027287; Flavi_E_Ig-like.
DR   InterPro; IPR026470; Flavi_E_Stem/Anchor_dom.
DR   InterPro; IPR038345; Flavi_E_Stem/Anchor_dom_sf.
DR   InterPro; IPR011998; Flavi_Glycoprot_E_cen/dimer.
DR   InterPro; IPR002535; Flavi_propep.
DR   InterPro; IPR038688; Flavi_propep_sf.
DR   InterPro; IPR000336; Flavivir/Alphavir_Ig-like_sf.
DR   InterPro; IPR036253; Glycoprot_cen/dimer_sf.
DR   InterPro; IPR038055; Glycoprot_E_dimer_dom.
DR   InterPro; IPR013756; GlyE_cen_dom_subdom2.
DR   InterPro; IPR014756; Ig_E-set.
DR   NCBIfam; TIGR04240; flavi_E_stem; 1.
DR   Pfam; PF01003; Flavi_capsid; 1.
DR   Pfam; PF21659; Flavi_E_stem; 1.
DR   Pfam; PF02832; Flavi_glycop_C; 1.
DR   Pfam; PF00869; Flavi_glycoprot; 1.
DR   Pfam; PF01004; Flavi_M; 1.
DR   Pfam; PF01570; Flavi_propep; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF101257; Flavivirus capsid protein C; 1.
DR   SUPFAM; SSF56983; Viral glycoprotein, central and dimerisation domains; 1.
PE   4: Predicted;
KW   Clathrin-mediated endocytosis of virus by host
KW   {ECO:0000256|ARBA:ARBA00022570};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Fusion of virus membrane with host endosomal membrane
KW   {ECO:0000256|ARBA:ARBA00022510};
KW   Fusion of virus membrane with host membrane
KW   {ECO:0000256|ARBA:ARBA00022506};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW   Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        718..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        754..772
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..110
FT                   /note="Capsid protein C flavivirus"
FT                   /evidence="ECO:0000259|Pfam:PF01003"
FT   DOMAIN          119..203
FT                   /note="Flavivirus polyprotein propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF01570"
FT   DOMAIN          206..278
FT                   /note="Envelope glycoprotein M flavivirus"
FT                   /evidence="ECO:0000259|Pfam:PF01004"
FT   DOMAIN          281..575
FT                   /note="Envelope glycoprotein E central and dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF00869"
FT   DOMAIN          577..672
FT                   /note="Glycoprotein E immunoglobulin-like"
FT                   /evidence="ECO:0000259|Pfam:PF02832"
FT   DOMAIN          675..769
FT                   /note="Flavivirus envelope glycoprotein E Stem/Anchor"
FT                   /evidence="ECO:0000259|Pfam:PF21659"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABD15346.1"
FT   NON_TER         774
FT                   /evidence="ECO:0000313|EMBL:ABD15346.1"
SQ   SEQUENCE   774 AA;  86066 MW;  28DF50282D192E6E CRC64;
     NNQRKKARST PFNMLKRERN RVSTVQQLTK RFSLGMLQGR GPLKLFMALV AFLRFLTIPP
     TAGILKRWGT IKKSKAINVL RGFRKEIGRM LNILNRRRRT AGVIIMLIPT AMAFHLTTRN
     GEPHMIVGRQ EKGKSLLFKT EDGVNMCTLM AIDLGELCED TITYKCPLLR QNEPEDIDCW
     CNSTSTWVTY GTCTTTGEHR REKRSVALVP HVGMGLETRT ETWMSSEGAW KHVQRIETWI
     LRHPGFTIMA AILAYTIGTT HFQRALIFIL LTAVAPSMTM RCIGISNRDF VEGVSGGSWV
     DIVLEHGSCV TTMAKNKPTL DFELIKTEAK QPATLRKYCI EAKLTNTTTE SRCPTQGEPS
     LNEEQDKRFV CKHSMVDRGW GNGCGLFGKG GIVTCAMFTC KKNMEGKVVL PENLEYTIVI
     TPHSGEEHAV GNDTGKHGKE IKITPQSSIT EAELTGYGTV TMECSPRTGL DFNEMVLLQM
     EDKAWLVHRQ WFLDLPLPWL PGADTQGSNW IQKETLVTFK NPHAKKQDVV VLGSQEGAMH
     TALTGATEIQ MSSGNLLFTG HLKCRLRMDK LQLKGMSYSM CTGKFKIVKE IAETQHGTIV
     IRVQYEGDGS PCKIPFEIMD LEKRHVLGRL ITVNPIVTEK DSPVNIEAEP PFGDSYIIIG
     VEPGQLKLNW FKKGSSIGQM FETTMRGAKR MAILGDTAWD FGSLGGVFTS IGKALHQVFG
     AIYGAAFSGV SWTMKILIGV IITWIGMNSR STSLSVSLVL VGVVTLYLGA MVQA
//
DBGET integrated database retrieval system