ID ADH_STAA3 Reviewed; 336 AA.
AC Q2FJ31;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 01-MAY-2013, entry version 54.
DE RecName: Full=Alcohol dehydrogenase;
DE Short=ADH;
DE EC=1.1.1.1;
GN Name=adh; OrderedLocusNames=SAUSA300_0594;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/S0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone +
CC NADH.
CC -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family.
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DR EMBL; CP000255; ABD21978.1; -; Genomic_DNA.
DR RefSeq; YP_493297.1; NC_007793.1.
DR ProteinModelPortal; Q2FJ31; -.
DR SMR; Q2FJ31; 1-336.
DR STRING; 451515.SAUSA300_0594; -.
DR EnsemblBacteria; ABD21978; ABD21978; SAUSA300_0594.
DR GeneID; 3914232; -.
DR KEGG; saa:SAUSA300_0594; -.
DR PATRIC; 19590473; VBIStaAur129981_0666.
DR eggNOG; COG1064; -.
DR HOGENOM; HOG000294685; -.
DR KO; K13953; -.
DR OMA; ATHCIVN; -.
DR ProtClustDB; PRK09422; -.
DR BioCyc; SAUR451515:GH3C-652-MONOMER; -.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:EC.
DR GO; GO:0048037; F:cofactor binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR013149; ADH_C.
DR InterPro; IPR013154; ADH_GroES-like.
DR InterPro; IPR002085; ADH_SF_Zn-type.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR InterPro; IPR011032; GroES-like.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR PANTHER; PTHR11695; PTHR11695; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES_like; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Complete proteome; Metal-binding; NAD; Oxidoreductase; Zinc.
FT CHAIN 1 336 Alcohol dehydrogenase.
FT /FTId=PRO_0000273032.
FT METAL 37 37 Zinc 1; catalytic (By similarity).
FT METAL 58 58 Zinc 1; catalytic (By similarity).
FT METAL 89 89 Zinc 2 (By similarity).
FT METAL 92 92 Zinc 2 (By similarity).
FT METAL 95 95 Zinc 2 (By similarity).
FT METAL 103 103 Zinc 2 (By similarity).
FT METAL 145 145 Zinc 1; catalytic (By similarity).
SQ SEQUENCE 336 AA; 36048 MW; DB68A432F9E72EF9 CRC64;
MRAAVVTKDH KVSIEDKKLR ALKPGEALVQ TEYCGVCHTD LHVKNADFGD VTGVTLGHEG
IGKVIEVAED VESLKIGDRV SIAWMFESCG RCEYCTTGRE TLCRSVKNAG YTVDGAMAEQ
VIVTADYAVK VPEKLDPAAA SSITCAGVTT YKAVKVSNVK PGQWLGVFGI GGLGNLALQY
AKNVMGAKIV AFDINDDKLA FAKELGADAI INSKDVDPVA EVMKLTDNKG LDATVVTSVA
KTPFNQAVDV VKAGARVVAV GLPVDKMNLD IPRLVLDGIE VVGSLVGTRQ DLREAFEFAA
ENKVTPKVQL RKLEEINDIF EEMENGTITG RMVIKF
//
