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Database: UniProt
Entry: Q2FZS8_STAA8
LinkDB: Q2FZS8_STAA8
Original site: Q2FZS8_STAA8 
ID   Q2FZS8_STAA8            Unreviewed;       869 AA.
AC   Q2FZS8;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   OrderedLocusNames=SAOUHSC_00912 {ECO:0000313|EMBL:ABD30037.1};
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061 {ECO:0000313|EMBL:ABD30037.1, ECO:0000313|Proteomes:UP000008816};
RN   [1] {ECO:0000313|Proteomes:UP000008816}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47 {ECO:0000313|Proteomes:UP000008816};
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C
RL   (2006).
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR   EMBL; CP000253; ABD30037.1; -; Genomic_DNA.
DR   RefSeq; WP_000353970.1; NZ_LS483365.1.
DR   RefSeq; YP_499465.1; NC_007795.1.
DR   AlphaFoldDB; Q2FZS8; -.
DR   SMR; Q2FZS8; -.
DR   STRING; 93061.SAOUHSC_00912; -.
DR   PaxDb; 1280-SAXN108_0969; -.
DR   GeneID; 3920799; -.
DR   KEGG; sao:SAOUHSC_00912; -.
DR   PATRIC; fig|93061.5.peg.833; -.
DR   eggNOG; COG0542; Bacteria.
DR   HOGENOM; CLU_005070_4_0_9; -.
DR   OMA; GPEHILM; -.
DR   OrthoDB; 9803641at2; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034};
KW   Hydrolase {ECO:0000313|EMBL:ABD30037.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:ABD30037.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008816};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016,
KW   ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN          3..145
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          50..106
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
FT   COILED          411..525
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
SQ   SEQUENCE   869 AA;  98331 MW;  9CC9FA8948FC060D CRC64;
     MDINKMTYAV QSALQQAVEL SQQHKLQNIE IEAILSAALN ESESLYKSIL ERVNIEVDQL
     NKAYEDKLNT YASVEGDNIQ YGQYISQQAN QLITKAESYM KEYEDEYISM EHILRSAMDI
     DQTTKHYINN KVEVIKEIIK KVRGGNHVTS QNPEVNYEAL AKYGRDLVEE VRQGKMDPVI
     GRDEEIRNTI RILSRKTKNN PVLIGEPGVG KTAIVEGLAQ RIVKKDVPES LLDKTVFELD
     LSALVAGAKY RGEFEERLKA VLKEVKESDG RIILFIDEIH MLVGAGKTDG AMDAGNMLKP
     MLARGELHCI GATTLNEYRE YIEKDSALER RFQKVAVSEP DVEDTISILR GLKERYEVYH
     GVRIQDRALV AAAELSDRYI TDRFLPDKAI DLVDQACATI RTEMGSNPTE LDQVNRRVMQ
     LEIEESALKN ESDNASKQRL QELQEELANE KEKQAALQSR VESEKEKIAN LQEKRAQLDE
     SRQALEDAQT NNNLEKAAEL QYGTIPQLEK ELRELEDNFQ DEQGEDTDRM IREVVTDEEI
     GDIVSQWTGI PVSKLVETER EKLLHLSDIL HKRVVGQDKA VDLVSDAVVR ARAGIKDPNR
     PIGSFLFLGP TGVGKTELAK SLAASLFDSE KHMIRIDMSE YMEKHAVSRL IGAPPGYIGH
     DEGGQLTEAV RRNPYSVILL DEVEKAHTDV FNVLLQILDE GRLTDSKGRS VDFKNTIIIM
     TSNIGSQVLL ENVKETGEIT ESTEKAVMTS LNAYFKPEIL NRMDDIVLFK PLSIDDMSMI
     VDKILTQLNI RLLEQRISIE VSDDAKAWLG QEAYEPQYGA RPLKRFVQRQ IETPLARMMI
     KEGFPEGTTI KVNLNSDNNL TFNVEKIHE
//
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