ID OTC_NOVAD Reviewed; 311 AA.
AC Q2G3J8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 29-MAY-2013, entry version 58.
DE RecName: Full=Ornithine carbamoyltransferase;
DE Short=OTCase;
DE EC=2.1.3.3;
GN Name=argF; OrderedLocusNames=Saro_3140;
OS Novosphingobium aromaticivorans (strain DSM 12444).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=279238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12444;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N.,
RA Fredrickson J., Balkwill D., Romine M.F., Richardson P.;
RT "Complete sequence of Novosphingobium aromaticivorans DSM 12444.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group
CC from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine
CC (ORN) to produce L-citrulline (By similarity).
CC -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate
CC + L-citrulline.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC arginine from L-ornithine and carbamoyl phosphate: step 1/3.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR EMBL; CP000248; ABD27575.1; -; Genomic_DNA.
DR RefSeq; YP_498409.1; NC_007794.1.
DR ProteinModelPortal; Q2G3J8; -.
DR SMR; Q2G3J8; 1-311.
DR STRING; 279238.Saro_3140; -.
DR EnsemblBacteria; ABD27575; ABD27575; Saro_3140.
DR GeneID; 3918182; -.
DR KEGG; nar:Saro_3140; -.
DR PATRIC; 22789136; VBINovAro50627_3220.
DR eggNOG; COG0078; -.
DR HOGENOM; HOG000022686; -.
DR OMA; IMIRTTE; -.
DR ProtClustDB; PRK00779; -.
DR BioCyc; NARO279238:GHBU-3212-MONOMER; -.
DR UniPathway; UPA00068; UER00112.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:HAMAP.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.40.50.1370; -; 2.
DR HAMAP; MF_01109; OTCase; 1; -.
DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR InterPro; IPR002292; Orn/put_carbamltrans.
DR InterPro; IPR024904; Orn_carbamltrans.
DR Pfam; PF00185; OTCace; 1.
DR Pfam; PF02729; OTCace_N; 1.
DR PRINTS; PR00100; AOTCASE.
DR PRINTS; PR00102; OTCASE.
DR SUPFAM; SSF53671; Asp/Orn_carbamoyltranf; 1.
DR TIGRFAMs; TIGR00658; orni_carb_tr; 1.
DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW Cytoplasm; Transferase.
FT CHAIN 1 311 Ornithine carbamoyltransferase.
FT /FTId=PRO_1000213570.
FT REGION 60 64 Carbamoyl phosphate binding (By
FT similarity).
FT REGION 138 141 Carbamoyl phosphate binding (By
FT similarity).
FT REGION 233 234 Ornithine binding (By similarity).
FT REGION 267 270 Carbamoyl phosphate binding (By
FT similarity).
FT BINDING 9 9 Carbamoyl phosphate (By similarity).
FT BINDING 87 87 Carbamoyl phosphate (By similarity).
FT BINDING 111 111 Carbamoyl phosphate (By similarity).
FT BINDING 169 169 Ornithine (By similarity).
FT BINDING 229 229 Ornithine (By similarity).
FT BINDING 278 278 Carbamoyl phosphate (By similarity).
FT BINDING 296 296 Carbamoyl phosphate (By similarity).
FT SITE 30 30 Important for structural integrity (By
FT similarity).
FT SITE 151 151 Important for structural integrity (By
FT similarity).
SQ SEQUENCE 311 AA; 33086 MW; E49EA03D88BF112A CRC64;
MSQALKHFLN LTDAGGDAIA AMLNDALDRK SARAGQPKGK ADADAPLGGR VLAMVFEKNS
TRTRVSFDIA MRQLGGSALI LDAGTTQLGR GETIADTARV LSRMADAIML RTDDHAKVEE
LARHATVPVI NGLTDLSHPC QIMADLLTVI EHGKALPGLE VAWLGDGNNV LNSIVEAAGL
MKFNVRIGVP EGYESDAGMI EAAVLAGAGI RVIRDPVEAV RGADVVVTDT WISMGQAHAE
AKLAAMAPYQ VNDALMAHAK PDAVFLHCLP AHRGEEVTDA VIDGPRSVVW DEAENRIHAQ
KSVLRWVFGQ I
//
