ID Q2GEH8_NEOSM Unreviewed; 477 AA.
AC Q2GEH8;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=TldD protein {ECO:0000313|EMBL:ABD46076.1};
GN Name=tldD {ECO:0000313|EMBL:ABD46076.1};
GN OrderedLocusNames=NSE_0224 {ECO:0000313|EMBL:ABD46076.1};
OS Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia
OS sennetsu).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Neorickettsia.
OX NCBI_TaxID=222891 {ECO:0000313|EMBL:ABD46076.1, ECO:0000313|Proteomes:UP000001942};
RN [1] {ECO:0000313|EMBL:ABD46076.1, ECO:0000313|Proteomes:UP000001942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-367 / Miyayama {ECO:0000313|Proteomes:UP000001942};
RX PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.,
RA Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C.,
RA Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D.,
RA Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT "Comparative genomics of emerging human ehrlichiosis agents.";
RL PLoS Genet. 2:208-222(2006).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP000237; ABD46076.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2GEH8; -.
DR STRING; 222891.NSE_0224; -.
DR KEGG; nse:NSE_0224; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_5; -.
DR Proteomes; UP000001942; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 36..91
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 128..234
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 241..475
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 477 AA; 51321 MW; 466323D11F82C9F9 CRC64;
MRSEVQVFSS PPFYMLDLEK FIPVVVSALQ GADGGELFVE YSLSEILKFE DGVLAESNYA
DSSGFGLRAF YGDKVLYTHS SHLSDASIFE ASDFIRKNRL ADGSAMTAEA AHETACGDPL
YKFEIQDDSF SFERKVAFLR QVYDYALSKS VNIASASVTL MRFVRRIGII KNTGGTVTDE
QPMVRLGFSV VLKNEKGGAQ GGTSGKGGRF ALSELMKDWY VVVDRAFHKA EVALRAVPCP
SGEMTVVLGS GWPGVLLHEA IGHGLEADFN RKGVSAFSGL IGKKVASDVV SVVDNGRINE
ARGSINVDDE GTRSSYNVLI KDGILQGYMF DLMNARLMGE QSTGNGRRES YMNIPLPRMT
NTYMLPGDKT PDEIIKSIKS GIYAVDFSGG QVDITSGKFV FSASEAYLIE DGEVTVPVKE
VTLIGDGPTI LKRISAVGND LKLDDGVGTC GKDGQSVPVC VGQPTICVDK ITVGGTA
//
