ID SUCC_ANAPZ Reviewed; 388 AA.
AC Q2GJ42;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 01-MAY-2013, entry version 58.
DE RecName: Full=Succinyl-CoA ligase [ADP-forming] subunit beta;
DE EC=6.2.1.5;
DE AltName: Full=Succinyl-CoA synthetase subunit beta;
DE Short=SCS-beta;
GN Name=sucC; OrderedLocusNames=APH_1052;
OS Anaplasma phagocytophilum (strain HZ).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Anaplasma; phagocytophilum group.
OX NCBI_TaxID=212042;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HZ;
RX PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S.,
RA Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N.,
RA Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P.,
RA Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H.,
RA Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F.,
RA Forberger H., Halpin R., Mulligan S., Robinson J., White O.,
RA Rikihisa Y., Tettelin H.;
RT "Comparative genomics of emerging human ehrlichiosis agents.";
RL PLoS Genet. 2:208-222(2006).
CC -!- CATALYTIC ACTIVITY: ATP + succinate + CoA = ADP + phosphate +
CC succinyl-CoA.
CC -!- COFACTOR: Binds 1 magnesium or manganese ion per subunit (By
CC similarity).
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC succinate from succinyl-CoA (ligase route): step 1/1.
CC -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits (By
CC similarity).
CC -!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta
CC subunit family.
CC -!- SIMILARITY: Contains 1 ATP-grasp domain.
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DR EMBL; CP000235; ABD44388.1; -; Genomic_DNA.
DR RefSeq; YP_505609.1; NC_007797.1.
DR HSSP; P53590; 2FP4.
DR ProteinModelPortal; Q2GJ42; -.
DR STRING; 212042.APH_1052; -.
DR EnsemblBacteria; ABD44388; ABD44388; APH_1052.
DR GeneID; 3930725; -.
DR KEGG; aph:APH_1052; -.
DR PATRIC; 20950858; VBIAnaPha602_1128.
DR eggNOG; COG0045; -.
DR HOGENOM; HOG000007059; -.
DR KO; K01903; -.
DR OMA; VANANEM; -.
DR ProtClustDB; PRK00696; -.
DR BioCyc; APHA212042:GHPM-1058-MONOMER; -.
DR UniPathway; UPA00223; UER00999.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR GO; GO:0030145; F:manganese ion binding; IEA:HAMAP.
DR GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; ISS:TIGR.
DR GO; GO:0006099; P:tricarboxylic acid cycle; ISS:TIGR.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.30.470.20; -; 1.
DR Gene3D; 3.40.50.261; -; 1.
DR HAMAP; MF_00558; Succ_CoA_beta; 1; -.
DR InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR013816; ATP_grasp_subdomain_2.
DR InterPro; IPR005811; CoA_ligase.
DR InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
DR InterPro; IPR005809; Succ_CoA_synthase_bsu.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR11815; PTHR11815; 1.
DR Pfam; PF08442; ATP-grasp_2; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PIRSF; PIRSF001554; SucCS_beta; 1.
DR SUPFAM; SSF52210; CoA_ligase; 1.
DR TIGRFAMs; TIGR01016; sucCoAbeta; 1.
DR PROSITE; PS50975; ATP_GRASP; FALSE_NEG.
DR PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Ligase; Magnesium; Manganese;
KW Metal-binding; Nucleotide-binding; Tricarboxylic acid cycle.
FT CHAIN 1 388 Succinyl-CoA ligase [ADP-forming] subunit
FT beta.
FT /FTId=PRO_1000081999.
FT DOMAIN 9 244 ATP-grasp.
FT NP_BIND 35 108 ATP (By similarity).
FT METAL 197 197 Magnesium or manganese (By similarity).
FT METAL 199 199 Magnesium or manganese (By similarity).
SQ SEQUENCE 388 AA; 41378 MW; 4B924E1E284DD8F5 CRC64;
MNVHEFQAKG ILSGFDVRVP KGVVVRSVEE VDSALGSLAA GIVAVKAQIH AGGRGKAGGV
KIGKAREEVA DLVKSMLGSV LVTHQTSAAG QKVHAVYLEE GVSIKKEYYL GAVVDRKAGM
VSVIFSSEGG MDIEEVAHSR PEMVVVVNVD PVYGFLDFHG RKLCYGLGLK KEQVVQITAM
ARKVCRALME TDASQVEINP LVETTCGEFI ALDAKMTFDD NGLFRRPEIV KLTDPHEYSE
EELEAAKYGL SYIKLDGNIG CMVNGAGLAM ATMDIVKYYG GEPANFLDVG GGASKDTVRE
AFKIILRSGV DGILVNIFGG IMRCDVIAAG IIESAKEIGV SVPMVVRLSG TNYKIGKEML
DASGLSIVTA ENLDEAARFV VDLVGKRG
//
