ID Q2GMR4_CHAGB Unreviewed; 1279 AA.
AC Q2GMR4;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN ORFNames=CHGG_10740 {ECO:0000313|EMBL:EAQ82922.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ82922.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
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DR EMBL; CH408036; EAQ82922.1; -; Genomic_DNA.
DR RefSeq; XP_001226007.1; XM_001226006.1.
DR AlphaFoldDB; Q2GMR4; -.
DR GeneID; 4397261; -.
DR VEuPathDB; FungiDB:CHGG_10740; -.
DR eggNOG; KOG1075; Eukaryota.
DR HOGENOM; CLU_000680_23_2_1; -.
DR InParanoid; Q2GMR4; -.
DR OrthoDB; 1368934at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 694..943
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 58..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..57
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1279 AA; 142373 MW; E254C39E66931A57 CRC64;
MYRMITEQRN TIGELREVIC KQHDAIQELH RQLADTRTQL SEELRQARDQ IDTLQRHPVA
MASSQPSARG SYAEVARTPP SSQPSGVRTL SSRNTTPSSF TDTLFCTIDT SRVEEKEKGN
VQVADIRKAI ETEARAQESM GDWRCAAVVK EARNPDRVRV ICQGRRRGPA RQGSGREDQC
SWSAGIERPV VPGEGRQCQP EQRSSMRTGN ILPGAAEALG TENDVNIAKI AWLSRKDTSK
AYGSMVVYVT KGSEARRLLD GRYFHLAGES AYTTVFAPRE GPIQCYRCQE IGHKAFACKK
PQRCGRCAEQ GHHHKTCQSV VLKCVLCRGF HTSHLARTVG AGHLRTICQA DRRLGDDGPN
ESSQLDEAYT NDKTRNHVAN SEHAMGGFET EQGRERISSW RAIFNRHDQL WGGDDVSPRR
QGEGDRIINL MDEHSLCSLL PRGTKTWQSG DIESTIDLVL ASAELADQLL RCTIHPCDHG
SDHRAIETAF DTTVEDRPSE TRFLFKNAPW AEIRTRVAAN LERIPWDGNV QQQTDRLMAA
VTEAVYGLTP KAKPSPYAKR WWTTDLTRLR QTYTFWRNQA RSRPTKYLQT GSGTMGDKIP
PLVRPDGSIT EGKAEQAQEL LTAFFPPLPA RIEDEGQRPQ RAPVHMPDLT MEEIEQKVLS
AKPWKAPGED GLPAMVWRQL WPVVKDRVLH LFRTSLRDGD IPSQWKNAKI IPLKKPGKSD
YTLAKSWRPI SLLSTLGKIL EAVIAERLSH AVETCGLLPA NHFGARKRRS TEQALLLLQE
HIYKAWRARK VLSLVSFDVK GAYNGVFKDR LLQRLKARGI PESLVKWIDA FCSKRTATIA
VNGFTSGRQE LPQAGLPQGS PLSPVLFLFF NADLVQHKID ANGGAIAFVE RLHCLGAQKI
GALAITGAFR TAATAVVEAE ASIYPVRERH AQAAASLWIN IHTLPGTHPL AMKKVRNTVR
FVSPLQKIAR VAEGVRVDRM ETIQEYAVPP WVPRLRPTLE ADRGKAAEMV NKISGIVIAT
SSSVKKGIVG MGGLARDTLF NRTSETVTNY AVVLGTREEQ NPYTAELAAI AMALEKLPAS
ICHRHITIDF ALGSDAKAAA QRASKQGRTP DSQIPQAKST AMRLAMERQR ATRVLPVSVG
KFSKAMDAAL PGKHTRHLYD KLKRREACVL AQLRTGMARL NGFLSRIGAV ESDLCACGQA
RESVEHFLFR CLRWTALRED MLQCTVARRG SLSFYLGGKA PSDTRHWSPD MKAVRATIKY
AMATGRLELN EEESLDQSQ
//
