ID Q2GNM7_CHAGB Unreviewed; 503 AA.
AC Q2GNM7;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=Chromatin modification-related protein EAF3 {ECO:0000256|ARBA:ARBA00018505};
GN ORFNames=CHGG_10427 {ECO:0000313|EMBL:EAQ84023.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ84023.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC {ECO:0000256|ARBA:ARBA00011353}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MRG family. {ECO:0000256|ARBA:ARBA00009093}.
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DR EMBL; CH408035; EAQ84023.1; -; Genomic_DNA.
DR RefSeq; XP_001228354.1; XM_001228353.1.
DR AlphaFoldDB; Q2GNM7; -.
DR STRING; 306901.Q2GNM7; -.
DR GeneID; 4396092; -.
DR VEuPathDB; FungiDB:CHGG_10427; -.
DR eggNOG; KOG3001; Eukaryota.
DR HOGENOM; CLU_027077_0_0_1; -.
DR InParanoid; Q2GNM7; -.
DR OMA; PQWNEMN; -.
DR OrthoDB; 2878816at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18983; CBD_MSL3_like; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.274.30; MRG domain; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR008676; MRG.
DR InterPro; IPR038217; MRG_C_sf.
DR InterPro; IPR026541; MRG_dom.
DR InterPro; IPR025995; Tudor-knot.
DR PANTHER; PTHR10880; MORTALITY FACTOR 4-LIKE PROTEIN; 1.
DR PANTHER; PTHR10880:SF15; MRG DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05712; MRG; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS51640; MRG; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 13..65
FT /note="Tudor-knot"
FT /evidence="ECO:0000259|Pfam:PF11717"
FT DOMAIN 359..490
FT /note="MRG"
FT /evidence="ECO:0000259|Pfam:PF05712"
FT REGION 94..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 56651 MW; 8B2996138245F365 CRC64;
MAPQKQQLPP FQKDERVLCF HMEMLYEAKI LDVMDAENGD GWLYKIHYKG WKSSWDDWVP
QDRVRKFTDE NKDLASQLLA QYKMLQSGKA AKQTAKKGGA AARAANGSDM SSARGSEERT
AGTTTTSGRG PRRARDYELE QGCFGMLWED ALGRFAAAFP AFKIASNTQE EHPNNIPEQL
VRRYDQVTTT GAGSPCCTPW RPCIKHCNGR RRNHIKNSAP VHETSGIQNP DRVRKPTRAR
KSSRVQKNVR LQNPSDGQPL SDGQPLSDGQ PLSDGQPLSD GQPLSDGQNP RDVPKSAQKI
TIFHKTADGT KSVTLTTPPT SPEAKNSRLP TPSLEEAAWK EPKLARDNLL RLPTIRTSKY
LDHNGRKTFD NRYPNRQEGS ASLDILEEAI AGLREYFDKA LGRILLYHFE RGQYHEMHKL
WNQADADGKH KSAADTYGAE HLARLLVSLP ELIAQTNMDQ QSVNRLREEL LKFISWFSRH
GVKYFASQYE TPGAAYRAQL ESH
//
