ID Q2H7F2_CHAGB Unreviewed; 747 AA.
AC Q2H7F2;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=DNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHGG_05413 {ECO:0000313|EMBL:EAQ88794.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ88794.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CH408031; EAQ88794.1; -; Genomic_DNA.
DR RefSeq; XP_001221508.1; XM_001221507.1.
DR AlphaFoldDB; Q2H7F2; -.
DR STRING; 306901.Q2H7F2; -.
DR GeneID; 4390141; -.
DR VEuPathDB; FungiDB:CHGG_05413; -.
DR eggNOG; KOG0351; Eukaryota.
DR HOGENOM; CLU_001103_9_2_1; -.
DR InParanoid; Q2H7F2; -.
DR OMA; TRMKTDR; -.
DR OrthoDB; 5474026at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd18018; DEXHc_RecQ4-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF150; ATP-DEPENDENT DNA HELICASE RECQ; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 105..289
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 316..459
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 30..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 82918 MW; 4998DF27908864F5 CRC64;
MSAFGSGDNL FDDVDVDQLV ASQPLASTGN LKRTCDHETE VNSRGNQRKK QRNNSGGIID
ENPVPDDGVL KELQPENVAQ MEVAQKLLTE TFGYSSFRHE QAGAIGRILA GGNVLTVFPT
GAGKSLCYQI PATAFPQLDL QDASRTPGEH GITIVVSPLI ALMKDQVDAL KRKKVAADCI
DSTKTWEQLQ QTYAALREGK LRILYCAPER LNNEGFVAMM RHVRGGVRLL AVDEAHCISE
WGHSFRPEYL KVARFADEIA AERVICLTAT ATPKVVDDIC SAFKIPTEGV FRTSAYRPNL
NLHARAVKTK HDKYPLLFQF LNENPGPTLV YVTLQQQSVL LAADLREHGF DAEAFHAGMK
VDEKSEIQDS FLANDIRIVV ATIAFGMGID KPDIRNVVHF DLSSTVEEYC QQVGRAGRDG
KTANCMFYIC PDDRYIRENF ARGDLPSRKS LKGLLIDILG KNAAKPVGDT FKTSHYAQSR
DYDIRMSPLV IIYAALELRF GLIRAVTPEY SEYKFVATPG YFTRMKTDRS PASRAISTNA
FKKAKFHHVD LTTIMSRTGL PRIDLVRTLN ELHETGLIEL KAGGIEQKYR IVQPLPRKGS
PAFATLLDDL HADLHADLSR READALCRTQ QVEDLVTGDR CLALALAQHF GMGLPGGKSK
CGHCTHCLTG RRVVMPPKRL RKPDLAGIGR ILAACDVRDD PRFLARIAFG IKSPRVIQLK
MHKHPVFMTL ADHDFEEFEK ACEGTAE
//
