ID   Q2HV09_MEDTR            Unreviewed;       357 AA.
AC   Q2HV09;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Peptidase C1A, papain; Somatotropin hormone; Peptidase C1, propeptide {ECO:0000313|EMBL:ABD32840.1};
GN   ORFNames=MtrDRAFT_AC149038g3v2 {ECO:0000313|EMBL:ABD32840.1};
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3880 {ECO:0000313|EMBL:ABD32840.1};
RN   [1] {ECO:0000313|EMBL:ABD32840.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Town C.D.;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABD32840.1}
RP   NUCLEOTIDE SEQUENCE.
RG   The International Medicago Genome Annotation Group;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
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DR   EMBL; AC149038; ABD32840.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2HV09; -.
DR   MEROPS; C01.049; -.
DR   ProMEX; Q2HV09; -.
DR   EnsemblPlants; AES82321; AES82321; MTR_7g111060.
DR   Gramene; AES82321; AES82321; MTR_7g111060.
DR   OMA; DEKIPYW; -.
DR   ExpressionAtlas; Q2HV09; differential.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR025660; Pept_his_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR012599; Propeptide_C1A.
DR   PANTHER; PTHR12411:SF895; CATHEPSIN B; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   Pfam; PF08127; Propeptide_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..357
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018540288"
FT   DOMAIN          101..336
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
SQ   SEQUENCE   357 AA;  39449 MW;  37974B5A0795384D CRC64;
     MAPTILPLVT LFLAFSVSYL SIGDAETDEK LNGLKLNSHI LQESIAKQIN ENPEAGWEAA
     INPRFSNFTV GQFKRLLGVK QAPKKELLST PVVTHPKSLK LPKEFDARTA WSQCSTIGKI
     LDQGHCGSCW AFGAVESLQD RFCIHFDMNI SLSVNDLLAC CGFLCGAGCD GGTPIYAWRY
     LAHHGVVTEE CDPYFDQIGC SHPGCEPAYQ TPKCVRKCVK GNQIWKRSKH YSVKAYRVKS
     DPQDIMAEVY KNGPVEVAFT VFEDFAHYKS GVYKHITGSA LGGHAVKLIG WGTSDEGEDY
     WLLANQWNTN WGDDGYFKIK RGTNECGIED DVTAGLPSTK NIVREVTDMD VDAGVSF
//