ID Q2I6C8_ORFV Unreviewed; 166 AA.
AC Q2I6C8;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Interferon resistance protein {ECO:0000313|EMBL:ABB84397.1};
DE Flags: Fragment;
OS Orf virus (ORFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Parapoxvirus.
OX NCBI_TaxID=10258 {ECO:0000313|EMBL:ABB84397.1};
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1] {ECO:0000313|EMBL:ABB84397.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7389/03 {ECO:0000313|EMBL:ABB84397.1};
RX PubMed=16757136; DOI=10.1016/j.vetmic.2006.04.020;
RA Kottaridi C., Nomikou K., Teodori L., Savini G., Lelli R., Markoulatos P.,
RA Mangana O.;
RT "Phylogenetic correlation of Greek and Italian orf virus isolates based on
RT VIR gene.";
RL Vet. Microbiol. 116:310-316(2006).
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DR EMBL; DQ275172; ABB84397.1; -; Genomic_DNA.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0039580; P:suppression by virus of host PKR signaling; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR CDD; cd19875; DSRM_EIF2AK2-like; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR009179; E3L.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1.
DR PANTHER; PTHR46205:SF3; LOQUACIOUS, ISOFORM B; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF02295; z-alpha; 1.
DR PIRSF; PIRSF004008; VAC_E3L; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00550; Zalpha; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50139; Z_BINDING; 1.
PE 4: Predicted;
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host IRF3 by virus {ECO:0000256|ARBA:ARBA00022931};
KW Inhibition of host IRF7 by virus {ECO:0000256|ARBA:ARBA00022811};
KW Inhibition of host PKR by virus {ECO:0000256|ARBA:ARBA00023041};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023041};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 1..46
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 92..160
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABB84397.1"
SQ SEQUENCE 166 AA; 18050 MW; 7A34EE7A2A1B4523 CRC64;
DKLPAKQIAK ELGISKHEAN RQLYRLLDSN DVCCEDGNPP RWFVECAPAS PTEEDENSDT
EPMETEAGCD TLFGGDIDIM TQSSVIRLKS LNPVSAVNEF CMMTHRPLEF CETRSGGEDH
CPRFTCTITI SGKVVAAANG ASKKLARHAA CASALTILIN NCGIKF
//
