ID COXX_FRASC Reviewed; 289 AA.
AC Q2JCG7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 01-MAY-2013, entry version 55.
DE RecName: Full=Protoheme IX farnesyltransferase;
DE EC=2.5.1.-;
DE AltName: Full=Heme B farnesyltransferase;
DE AltName: Full=Heme O synthase;
GN Name=ctaB; OrderedLocusNames=Francci3_1649;
OS Frankia sp. (strain CcI3).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Frankineae; Frankiaceae; Frankia.
OX NCBI_TaxID=106370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CcI3;
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC hydroxyethyl farnesyl side group (By similarity).
CC -!- PATHWAY: Porphyrin metabolism; heme O biosynthesis; heme O from
CC protoheme: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (Potential).
CC -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC according to the Fischer nomenclature (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC Protoheme IX farnesyltransferase subfamily.
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DR EMBL; CP000249; ABD11025.1; -; Genomic_DNA.
DR RefSeq; YP_480754.1; NC_007777.1.
DR STRING; 106370.Francci3_1649; -.
DR EnsemblBacteria; ABD11025; ABD11025; Francci3_1649.
DR GeneID; 3905928; -.
DR KEGG; fra:Francci3_1649; -.
DR PATRIC; 21926334; VBIFraSp10456_1780.
DR eggNOG; COG0109; -.
DR HOGENOM; HOG000237291; -.
DR KO; K02301; -.
DR OMA; FRWSILY; -.
DR ProtClustDB; PRK04375; -.
DR BioCyc; FSP106370:GI1F-1719-MONOMER; -.
DR UniPathway; UPA00834; UER00712.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:HAMAP.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00154; CyoE_CtaB; 1; -.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR PROSITE; PS00943; UBIA; FALSE_NEG.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1 289 Protoheme IX farnesyltransferase.
FT /FTId=PRO_0000327055.
FT TRANSMEM 9 29 Helical; (Potential).
FT TRANSMEM 40 60 Helical; (Potential).
FT TRANSMEM 89 109 Helical; (Potential).
FT TRANSMEM 110 130 Helical; (Potential).
FT TRANSMEM 134 154 Helical; (Potential).
FT TRANSMEM 155 175 Helical; (Potential).
FT TRANSMEM 190 209 Helical; (Potential).
FT TRANSMEM 228 248 Helical; (Potential).
FT TRANSMEM 269 289 Helical; (Potential).
SQ SEQUENCE 289 AA; 31071 MW; 8B70326E30477941 CRC64;
MSAKARGYVA LMKLRVVELL LITTVPVMML AERGVPSLRL IAVTLVAGTL AAGSANTINC
YVDRDIDQMM GRTKRRPLVR ATVTPTEALT FGIVIGIVST LLFGFLVNWP SALLADGAIA
FYVFVYTLGL KRRTPSNIVI GGAAGCFPVL IGWSAVTGTV GWAAVLLFAV VFFWTPPHFW
ALAMKFRDDY AAAGVPMLPV VASVQVVTRR MLGYAYAMVA ASLAVAPVAS TGPVYLVAAV
AVGAWFLVES HRVARRARHG EDPRPMRLFH MSITYLTLLF VAIAVTALV
//
