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Database: UniProt
Entry: Q2JCG7
LinkDB: Q2JCG7
Original site: Q2JCG7 
ID   COXX_FRASC              Reviewed;         289 AA.
AC   Q2JCG7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   14-MAY-2014, entry version 60.
DE   RecName: Full=Protoheme IX farnesyltransferase;
DE            EC=2.5.1.-;
DE   AltName: Full=Heme B farnesyltransferase;
DE   AltName: Full=Heme O synthase;
GN   Name=ctaB; OrderedLocusNames=Francci3_1649;
OS   Frankia sp. (strain CcI3).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Frankineae; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CcI3;
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group (By similarity).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature (By similarity).
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily.
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DR   EMBL; CP000249; ABD11025.1; -; Genomic_DNA.
DR   RefSeq; YP_480754.1; NC_007777.1.
DR   STRING; 106370.Francci3_1649; -.
DR   EnsemblBacteria; ABD11025; ABD11025; Francci3_1649.
DR   GeneID; 3905928; -.
DR   KEGG; fra:Francci3_1649; -.
DR   PATRIC; 21926334; VBIFraSp10456_1780.
DR   eggNOG; COG0109; -.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; PTVNDRI; -.
DR   OrthoDB; EOG6DVJQB; -.
DR   BioCyc; FSP106370:GI1F-1681-MONOMER; -.
DR   UniPathway; UPA00834; UER00712.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN         1    289       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_0000327055.
FT   TRANSMEM      9     29       Helical; (Potential).
FT   TRANSMEM     40     60       Helical; (Potential).
FT   TRANSMEM     89    109       Helical; (Potential).
FT   TRANSMEM    110    130       Helical; (Potential).
FT   TRANSMEM    134    154       Helical; (Potential).
FT   TRANSMEM    155    175       Helical; (Potential).
FT   TRANSMEM    190    209       Helical; (Potential).
FT   TRANSMEM    228    248       Helical; (Potential).
FT   TRANSMEM    269    289       Helical; (Potential).
SQ   SEQUENCE   289 AA;  31071 MW;  8B70326E30477941 CRC64;
     MSAKARGYVA LMKLRVVELL LITTVPVMML AERGVPSLRL IAVTLVAGTL AAGSANTINC
     YVDRDIDQMM GRTKRRPLVR ATVTPTEALT FGIVIGIVST LLFGFLVNWP SALLADGAIA
     FYVFVYTLGL KRRTPSNIVI GGAAGCFPVL IGWSAVTGTV GWAAVLLFAV VFFWTPPHFW
     ALAMKFRDDY AAAGVPMLPV VASVQVVTRR MLGYAYAMVA ASLAVAPVAS TGPVYLVAAV
     AVGAWFLVES HRVARRARHG EDPRPMRLFH MSITYLTLLF VAIAVTALV
//
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