ID HIS7_RHIEC Reviewed; 202 AA.
AC Q2KE56;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 01-MAY-2013, entry version 49.
DE RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE Short=IGPD;
DE EC=4.2.1.19;
GN Name=hisB; OrderedLocusNames=RHE_CH00047;
OS Rhizobium etli (strain CFN 42 / ATCC 51251).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=347834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFN 42 / ATCC 51251;
RX PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT "The partitioned Rhizobium etli genome: genetic and metabolic
RT redundancy in seven interacting replicons.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC family.
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DR EMBL; CP000133; ABC88880.1; -; Genomic_DNA.
DR RefSeq; YP_467607.1; NC_007761.1.
DR ProteinModelPortal; Q2KE56; -.
DR SMR; Q2KE56; 7-189.
DR STRING; 347834.RHE_CH00047; -.
DR EnsemblBacteria; ABC88880; ABC88880; RHE_CH00047.
DR GeneID; 3893191; -.
DR KEGG; ret:RHE_CH00047; -.
DR PATRIC; 23081368; VBIRhiEtl108884_0376.
DR eggNOG; COG0131; -.
DR HOGENOM; HOG000228064; -.
DR KO; K01693; -.
DR OMA; HHIVEAC; -.
DR ProtClustDB; PRK00951; -.
DR BioCyc; RETL347834:GJJ0-47-MONOMER; -.
DR UniPathway; UPA00031; UER00011.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:HAMAP.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00076; HisB; 1; -.
DR InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR PANTHER; PTHR23133:SF2; PTHR23133:SF2; 1.
DR Pfam; PF00475; IGPD; 1.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 2.
DR PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR PROSITE; PS00955; IGP_DEHYDRATASE_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW Histidine biosynthesis; Lyase.
FT CHAIN 1 202 Imidazoleglycerol-phosphate dehydratase.
FT /FTId=PRO_0000336337.
SQ SEQUENCE 202 AA; 21803 MW; 0CE6106DFD9A86B0 CRC64;
MAETAASRTG SVARKTNETS ISVSVNLDGT GKSKISTGVG FFDHMLDQLS RHSLIDMEIE
AKGDLHIDDH HTVEDTGIAI GQAISKALGD RRGITRYASI DLAMDETMTK AAVDLSGRPF
LVWNVAFSAP KIGTFDTELV REFFQALAQN AGITLHLLNH YGANNHHIAE TCFKAVARAL
RTATEIDPRQ AGRVPSTKGT LV
//
