ID Q2KTA3_ORYLA Unreviewed; 880 AA.
AC Q2KTA3;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 100.
DE RecName: Full=Xylosyltransferase 2 {ECO:0000256|ARBA:ARBA00039683};
DE EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972};
DE AltName: Full=Xylosyltransferase II {ECO:0000256|ARBA:ARBA00041721};
GN Name=xt-II {ECO:0000313|EMBL:CAJ76255.1};
GN Synonyms=xylt2 {ECO:0000313|Ensembl:ENSORLP00000015322.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:CAJ76255.1};
RN [1] {ECO:0000313|EMBL:CAJ76255.1}
RP NUCLEOTIDE SEQUENCE.
RA Ouzzine M., Fournel-Gigleux S., Mollicone R., Oriol R.;
RT "Phylogeny of animal protein-O-xylosyltransferases.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSORLP00000015322.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015322.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [3] {ECO:0000313|Ensembl:ENSORLP00000015322.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015322.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-
CC L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA-
CC COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132085; EC=2.4.2.26;
CC Evidence={ECO:0000256|ARBA:ARBA00001814};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004840}.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT
CC subfamily. {ECO:0000256|ARBA:ARBA00010195}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM229409; CAJ76255.1; -; mRNA.
DR RefSeq; NP_001098317.1; NM_001104847.1.
DR STRING; 8090.ENSORLP00000015322; -.
DR CAZy; GT14; Glycosyltransferase Family 14.
DR Ensembl; ENSORLT00000015323.2; ENSORLP00000015322.1; ENSORLG00000012244.2.
DR GeneID; 100049492; -.
DR KEGG; ola:100049492; -.
DR CTD; 64132; -.
DR eggNOG; KOG0799; Eukaryota.
DR GeneTree; ENSGT00940000158326; -.
DR HOGENOM; CLU_012840_0_0_1; -.
DR OMA; GIQWDEI; -.
DR OrthoDB; 4166917at2759; -.
DR TreeFam; TF315534; -.
DR UniPathway; UPA00755; -.
DR UniPathway; UPA00756; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000012244; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030158; F:protein xylosyltransferase activity; IBA:GO_Central.
DR GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0050650; P:chondroitin sulfate proteoglycan biosynthetic process; IBA:GO_Central.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IBA:GO_Central.
DR InterPro; IPR003406; Glyco_trans_14.
DR InterPro; IPR043538; XYLT.
DR InterPro; IPR024448; XylT_C.
DR PANTHER; PTHR46025:SF1; XYLOSYLTRANSFERASE 2; 1.
DR PANTHER; PTHR46025; XYLOSYLTRANSFERASE OXT; 1.
DR Pfam; PF02485; Branch; 1.
DR Pfam; PF12529; Xylo_C; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:CAJ76255.1};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ76255.1}.
FT DOMAIN 536..714
FT /note="Xylosyltransferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12529"
FT REGION 43..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 99852 MW; A379320433118016 CRC64;
MVASVRVQKL LRRYKLAIAA ALTILLIQGL VVWSLRSLEE GEAERKTRRS KLPDHNGQDA
KKDSSLWANS NSLAWRSKGK WNIRFERTGG TAGSTQRKGN SGRGGKLTTR QKTPQEREMT
AAGLDGVVSH DLSSSRNLSD SHGGLDVGVK FPAAALPGEP GSVDGRTDQA LSNDFVPKCD
ITGKDALSAL HRAESQRCRQ EIANIVCQHQ AGKLMPHGFP QFCPHPGFSQ PVEAAGEEDF
SISKVKNPVR VAFVLMVHGR AVRQLKRLIK AIYHRDHFFY IHVDKRCSYM HREVLQMAKH
YPNIRATPWR MVTIWGGASL LKAYLRSMQD LLSMAEWKWD FFINLSATDF PTRTNDELVA
FLSQYRDKNF LKSHGRENTR FIKKQGLDRL FHECDNHMWR LGERSIPKGL EVSGGSDWFA
LTRPFVEYVI HSQDELVLGL KQFYSYALLP AESFFHTVLG NSHMCDTLVD NNLRVTNWNR
KLGCKCQYKH IVDWCGCSPN DFKPQDLIRI QQLSRPTFFA RKFESTVNQE AIEILDTHLY
GQYAPGTAAI KAYWESVFEQ LDGVGSLSDV ALTAYTSFIR LGLKSLMTSQ SDVEACRFEQ
VGFPLSVHLY FYDDHFQGYL VRQEVQTVGS KDRETLEVWA LPQTLVTFEL YPRDFERLKN
LEVGTEWDPK ERIFRNFGSV IGPLDEPLAV QKWARGQNLT ATIVWIDPAL VVAASYDINV
DADAEYTHYK PPLQHPLRPG KWTVQLLKQW QRVAKVNFLV MPLTFNNKEP LRREEDSWFH
SGPPGNVYLD HSLQQLSSVL KLPPQEPAMQ AALRNAQLVG QPLQEWVDRE VGSFWVIGSM
CSAQTSSCPA LGSCSKTTWS SYSPDPKSEL VQIKSDGRIR
//