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Database: UniProt
Entry: Q2KTA3_ORYLA
LinkDB: Q2KTA3_ORYLA
Original site: Q2KTA3_ORYLA 
ID   Q2KTA3_ORYLA            Unreviewed;       880 AA.
AC   Q2KTA3;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=Xylosyltransferase 2 {ECO:0000256|ARBA:ARBA00039683};
DE            EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972};
DE   AltName: Full=Xylosyltransferase II {ECO:0000256|ARBA:ARBA00041721};
GN   Name=xt-II {ECO:0000313|EMBL:CAJ76255.1};
GN   Synonyms=xylt2 {ECO:0000313|Ensembl:ENSORLP00000015322.1};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|EMBL:CAJ76255.1};
RN   [1] {ECO:0000313|EMBL:CAJ76255.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ouzzine M., Fournel-Gigleux S., Mollicone R., Oriol R.;
RT   "Phylogeny of animal protein-O-xylosyltransferases.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000015322.1, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015322.1,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [3] {ECO:0000313|Ensembl:ENSORLP00000015322.1}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000015322.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-
CC         L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA-
CC         COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132085; EC=2.4.2.26;
CC         Evidence={ECO:0000256|ARBA:ARBA00001814};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004840}.
CC   -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005093}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004606}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT
CC       subfamily. {ECO:0000256|ARBA:ARBA00010195}.
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DR   EMBL; AM229409; CAJ76255.1; -; mRNA.
DR   RefSeq; NP_001098317.1; NM_001104847.1.
DR   STRING; 8090.ENSORLP00000015322; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   Ensembl; ENSORLT00000015323.2; ENSORLP00000015322.1; ENSORLG00000012244.2.
DR   GeneID; 100049492; -.
DR   KEGG; ola:100049492; -.
DR   CTD; 64132; -.
DR   eggNOG; KOG0799; Eukaryota.
DR   GeneTree; ENSGT00940000158326; -.
DR   HOGENOM; CLU_012840_0_0_1; -.
DR   OMA; GIQWDEI; -.
DR   OrthoDB; 4166917at2759; -.
DR   TreeFam; TF315534; -.
DR   UniPathway; UPA00755; -.
DR   UniPathway; UPA00756; -.
DR   Proteomes; UP000001038; Chromosome 8.
DR   Bgee; ENSORLG00000012244; Expressed in gastrula and 14 other cell types or tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030158; F:protein xylosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0050650; P:chondroitin sulfate proteoglycan biosynthetic process; IBA:GO_Central.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   InterPro; IPR043538; XYLT.
DR   InterPro; IPR024448; XylT_C.
DR   PANTHER; PTHR46025:SF1; XYLOSYLTRANSFERASE 2; 1.
DR   PANTHER; PTHR46025; XYLOSYLTRANSFERASE OXT; 1.
DR   Pfam; PF02485; Branch; 1.
DR   Pfam; PF12529; Xylo_C; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:CAJ76255.1};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ76255.1}.
FT   DOMAIN          536..714
FT                   /note="Xylosyltransferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12529"
FT   REGION          43..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   880 AA;  99852 MW;  A379320433118016 CRC64;
     MVASVRVQKL LRRYKLAIAA ALTILLIQGL VVWSLRSLEE GEAERKTRRS KLPDHNGQDA
     KKDSSLWANS NSLAWRSKGK WNIRFERTGG TAGSTQRKGN SGRGGKLTTR QKTPQEREMT
     AAGLDGVVSH DLSSSRNLSD SHGGLDVGVK FPAAALPGEP GSVDGRTDQA LSNDFVPKCD
     ITGKDALSAL HRAESQRCRQ EIANIVCQHQ AGKLMPHGFP QFCPHPGFSQ PVEAAGEEDF
     SISKVKNPVR VAFVLMVHGR AVRQLKRLIK AIYHRDHFFY IHVDKRCSYM HREVLQMAKH
     YPNIRATPWR MVTIWGGASL LKAYLRSMQD LLSMAEWKWD FFINLSATDF PTRTNDELVA
     FLSQYRDKNF LKSHGRENTR FIKKQGLDRL FHECDNHMWR LGERSIPKGL EVSGGSDWFA
     LTRPFVEYVI HSQDELVLGL KQFYSYALLP AESFFHTVLG NSHMCDTLVD NNLRVTNWNR
     KLGCKCQYKH IVDWCGCSPN DFKPQDLIRI QQLSRPTFFA RKFESTVNQE AIEILDTHLY
     GQYAPGTAAI KAYWESVFEQ LDGVGSLSDV ALTAYTSFIR LGLKSLMTSQ SDVEACRFEQ
     VGFPLSVHLY FYDDHFQGYL VRQEVQTVGS KDRETLEVWA LPQTLVTFEL YPRDFERLKN
     LEVGTEWDPK ERIFRNFGSV IGPLDEPLAV QKWARGQNLT ATIVWIDPAL VVAASYDINV
     DADAEYTHYK PPLQHPLRPG KWTVQLLKQW QRVAKVNFLV MPLTFNNKEP LRREEDSWFH
     SGPPGNVYLD HSLQQLSSVL KLPPQEPAMQ AALRNAQLVG QPLQEWVDRE VGSFWVIGSM
     CSAQTSSCPA LGSCSKTTWS SYSPDPKSEL VQIKSDGRIR
//
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