ID Q2KTB2_9PSED Unreviewed; 474 AA.
AC Q2KTB2;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=S-adenosyl-L-homocysteine hydrolase {ECO:0000313|EMBL:CAJ76167.1};
DE EC=3.3.1.1 {ECO:0000313|EMBL:CAJ76167.1};
GN Name=sah {ECO:0000313|EMBL:CAJ76167.1};
OS Pseudomonas sp. 7197.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=349859 {ECO:0000313|EMBL:CAJ76167.1};
RN [1] {ECO:0000313|EMBL:CAJ76167.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7197 {ECO:0000313|EMBL:CAJ76167.1};
RA Zhang J., Zeng R.;
RT "Nucleotide sequence of S-adenosyl-L-homocysteine hydrolase gene from
RT Pseudomonas sp. 7197.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
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DR EMBL; AM229329; CAJ76167.1; -; Genomic_DNA.
DR AlphaFoldDB; Q2KTB2; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF05221; AdoHcyase; 2.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00738; ADOHCYASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CAJ76167.1};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT DOMAIN 210..350
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
SQ SEQUENCE 474 AA; 52775 MW; 5F9F16A273D85B82 CRC64;
MDAVSNTPSA HTIDPSFTDY KVADISLADY GRREITLAEA EMPALMGLRR RYEADQPLKG
AKIAGCIHMT IQTAVLIETL VALGAEVRWT SCNIFSTQDH AAAAIAAAGI SVYAWKGETE
EEYEWCLRQQ IHVGGEESGQ LWDANLILDD GGDLTALIHN DYAQMLDNIH GISEETTTGV
HRLVEMLGKG TLKVPAINVN DAVTKSKNDN KYGCRHSLND AIKRATDMFL AGRRALVIGY
GDVGKGSTKA YVKKACLSVY QKLILSVLCK PVWTAMKYCH LISMAITLAA QKTSILVCLK
ILTYLLPLPV TITFVTNICL RRSSRVRSYA TSVTSIPKLI RSLCVITGAG LRLSRKCIKS
SARMTKTIIR FCLLKVAWST KVMLLVTHRA CWMAHLLTKY WHKCTCLKKN SLSCQSMSAL
IIYTLKCYRK NLTKKLRRQW LQALTVHSRN RLKNKPSILA YLSKVRLSLT LINT
//
