ID Q2LD51_TAKRU Unreviewed; 201 AA.
AC Q2LD51;
DT 21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 21-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=Suppressor of cytokine signaling 3 {ECO:0000256|ARBA:ARBA00021410};
GN Name=socs3 {ECO:0000313|Ensembl:ENSTRUP00000029424.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:ABC73078.1};
RN [1] {ECO:0000313|EMBL:ABC73078.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H., Shao J., Xiang L.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABC73078.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16620988; DOI=10.1016/j.molimm.2006.03.003;
RA Jin H.J., Shao J.Z., Xiang L.X.;
RT "Identification and characterization of suppressor of cytokine signaling 3
RT (SOCS-3) homologues in teleost fish.";
RL Mol. Immunol. 44:1042-1051(2007).
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000029424.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [4] {ECO:0000313|Ensembl:ENSTRUP00000029424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; DQ335254; ABC73078.1; -; mRNA.
DR RefSeq; NP_001072096.1; NM_001078628.1.
DR STRING; 31033.ENSTRUP00000029424; -.
DR Ensembl; ENSTRUT00000029541.3; ENSTRUP00000029424.1; ENSTRUG00000011640.3.
DR GeneID; 778006; -.
DR KEGG; tru:778006; -.
DR CTD; 335409; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000159620; -.
DR HOGENOM; CLU_079452_3_0_1; -.
DR OMA; KLVHYYM; -.
DR OrthoDB; 5362214at2759; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0048681; P:negative regulation of axon regeneration; IEA:Ensembl.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031099; P:regeneration; IEA:Ensembl.
DR GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Ensembl.
DR CDD; cd10384; SH2_SOCS3; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035863; SOCS3_SH2.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF11; SUPPRESSOR OF CYTOKINE SIGNALING 3; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 50..158
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 153..200
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 201 AA; 22761 MW; 0D7DF7F957CD5630 CRC64;
MVTHSKFSNA MSSSLFDSNM RLPHHYKTFN SKSQYQMVLA TLHKLQESGF YWGAITGKDA
NVMLAAEDAG TFLIRDSSDN RHLFALSIKT ASGTKNLRIQ CDSSSFYLQT DPKNIQTVPH
FDCVLKLVHY YMSQSKGSTL YYIYSGAEKV PLELIKPLSC SLSTLQHLCR KTVNGLVDVS
SRRDQLPHHI KEFLQDYDAP I
//
