ID   Q2N3W3_CLODI            Unreviewed;       726 AA.
AC   Q2N3W3;
DT   07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   07-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=S-layer protein {ECO:0000313|EMBL:AAZ05966.1};
GN   Name=slpA {ECO:0000313|EMBL:AAZ05966.1};
OS   Clostridioides difficile (Peptoclostridium difficile).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=1496 {ECO:0000313|EMBL:AAZ05966.1};
RN   [1] {ECO:0000313|EMBL:AAZ05966.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HPA R13541 {ECO:0000313|EMBL:AAZ05964.1}, and HPA R13549
RC   {ECO:0000313|EMBL:AAZ05966.1};
RA   Ni Eidhin D.B., Ryan A.W., Doyle R.M., Walsh J.B., Kelleher D.P.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAZ05966.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HPA R13541 {ECO:0000313|EMBL:AAZ05964.1}, and HPA R13549
RC   {ECO:0000313|EMBL:AAZ05966.1};
RX   PubMed=16388033; DOI=10.1099/jmm.0.46204-0;
RA   Eidhin D.N., Ryan A.W., Doyle R.M., Walsh J.B., Kelleher D.;
RT   "Sequence and phylogenetic analysis of the gene for surface layer protein,
RT   slpA, from 14 PCR ribotypes of Clostridium difficile.";
RL   J. Med. Microbiol. 55:69-83(2006).
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DR   EMBL; DQ060628; AAZ05964.1; -; Genomic_DNA.
DR   EMBL; DQ060629; AAZ05966.1; -; Genomic_DNA.
DR   RefSeq; WP_021373624.1; NZ_VIMG01000002.1.
DR   SMR; Q2N3W3; -.
DR   GeneID; 66355200; -.
DR   GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.12090; -; 2.
DR   InterPro; IPR007253; Cell_wall-bd_2.
DR   NCBIfam; NF033435; S-layer_Clost; 1.
DR   PANTHER; PTHR30032:SF8; AMIDASE ENHANCER; 1.
DR   PANTHER; PTHR30032; N-ACETYLMURAMOYL-L-ALANINE AMIDASE-RELATED; 1.
DR   Pfam; PF04122; CW_binding_2; 3.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..726
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040663675"
SQ   SEQUENCE   726 AA;  76999 MW;  50505BC7F0CB0B98 CRC64;
     MNKKNLAVVM SAVTVIGSAA PVFAAAEDSF PNGNTTVSSS KYSDIERILK KYVADGVTGI
     TVNFFDKKGN PKGVSISSLE ASQISYVKDE IKDLKAGEYA KISVKITDGT EKKYDDTLLK
     ELDSNAVVTK VGTATTVKIV DQDGNSIEND AKLKLQKYDT TTSAYVDGAT KDEVLAATKA
     AVKTSKFTDK TGNNATGTVA ITATYADAVA GAIKLKYDTQ AAVAPTLDTA VASLDGTKEI
     YDFSKPVITV NTTDGTSKLS FEKTGEKVGA VESNVTVIAA SDETVTISGD AKEKAEALAK
     KYVFKDTELE DAYKTVTASD FEKTDNDYYE VVLYPTGKRL NTASTYASSN YKPELPTSDR
     VDTPAIITLR STNKNNLKSA LDELRTYNNS YSNNSVLAGD DRIETAIEIS KDSYNADGGI
     KGDYVEANEV VLVGSQSIVD GLVASPLAAV KDAPLLLTSK DKLDSSVKSE IKRVMGLDDK
     TGITSKKTVY IAGGENSVSK EVANELKDMG LKVERLSGDD RYATSLEIAD EIGLNHNKVF
     VVGGTGLADA MSIASVASNK EMPIVVVDGK GKDLSTDAKD FIGSAYVDII GGKSSVSEDM
     EDAIDDATGK SPERVSGDDR QDTNAEVIKT YFEKDNSDSV ISTGVKNFYV AKDGSTKEDQ
     LVDALAIAAV AGHNEAPIVL ATDSLSSDQS VAISKVTNSD DSKKLTQVGK GIADSVIKRI
     KDLLEL
//